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消旋卡多曲

消旋卡多曲用途

Racecadotril (acetorphan)是脑啡肽酶抑制剂,IC50为4.5 uM,能抑制内源的脑啡肽降解。

消旋卡多曲名称

[ CAS 号 ]:
81110-73-8

[ 中文名 ]:
消旋卡多曲

[ 英文名 ]:
Racecadotril

[中文别名 ]:

醋托泛

[英文别名 ]:

Acetorphan
Tiorfan
Hidrasec
Tiorfix
Redotil
MFCD00865520
Racecadotril
RACECADOTRIL: ACETORPHAN
RACECADORTRIL

消旋卡多曲生物活性

[ 描述 ]:

Racecadotril (acetorphan)是脑啡肽酶抑制剂,IC50为4.5 uM,能抑制内源的脑啡肽降解。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 脑啡肽酶

研究领域 >> 神经疾病

[参考文献]

[1]. Marion Eberlin, Tobias Mück, Martin C. Michel, et al. A Comprehensive Review of the Pharmacodynamics, Pharmacokinetics, and Clinical Effects of the Neutral Endopeptidase Inhibitor Racecadotril. Front Pharmacol. 2012; 3: 93.

[2]. Wu HT, Chang CK, Cheng KC, et al. Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats. Horm Metab Res. 2010 Apr;42(4):261-7.

[3]. Szajewska H, Ruszczyński M, Chmielewska A, Wieczorek J. Systematic review: racecadotril in the treatment of acute diarrhoea in children. Aliment Pharmacol Ther. 2007 Sep 15;26(6):807-13.

[4]. Schwartz JC. Racecadotril: a new approach to the treatment of diarrhoea. Int J Antimicrob Agents. 2000 Feb;14(1):75-9.

[5]. Racecadotril

[相关活性小分子]

消旋卡多曲物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
574.5±50.0 °C at 760 mmHg

[ 熔点 ]:
89ºC

[ 分子式 ]:
C₂₁H₂₃NO₄S

[ 分子量 ]:
385.477

[ 闪点 ]:
301.2±30.1 °C

[ 精确质量 ]:
385.134766

[ PSA ]:
97.77000

[ LogP ]:
3.44

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.579

[ 储存条件 ]:
Refrigerator

消旋卡多曲MSDS

详细MSDS(安全技术说明书)

消旋卡多曲安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H400

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
22-50/53

[ 安全声明 (欧洲) ]:
60-61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ RTECS号 ]:
MB7606872

[ 海关编码 ]:
2930909090

消旋卡多曲海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

消旋卡多曲文献

A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea.

J. Assoc. Physicians India 60 , 12-5, (2012)

To assess the efficacy of single dose of octreotide and compare it with another antisecretory agent racecadotril in the management of acute infective diarrhea.A randomized control study was done in th...

Racecadotril versus loperamide: antidiarrheal research revisited.

Dig. Dis. Sci. 48(2) , 239-50, (2003)

Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea. A critical review of the...

Quantitative analysis of racecadotril metabolite in human plasma using a liquid chromatography/tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 852(1-2) , 101-7, (2007)

Orally administered racecadotril is rapidly hydrolyzed to the more potent enkephalinase inhibitor thiorphan in vivo. A sensitive and specific liquid chromatography/tandem mass spectrometry method was ...

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