双酚a
双酚a用途
双酚a名称
[ CAS 号 ]:
80-05-7
[ 中文名 ]:
双酚A
[ 英文名 ]:
bisphenol A
[中文别名 ]:
[英文别名 ]:
- Parabis
- 2,2-Bis(4-hydroxyphenyl)propane
- Bicifadinum
- Phenol, 4,4'-(1-methylethylidene)bis-
- Hidorin F 285
- 4,4'-(1-Methylethane-1,1-diyl)diphenol
- EINECS 201-245-8
- Bis(p-hydroxyphenyl)propane
- MFCD03427359
- BPA
双酚a生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
Human Endogenous Metabolite
[参考文献]
双酚a物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
400.8±25.0 °C at 760 mmHg
[ 熔点 ]:
158-159 °C(lit.)
[ 分子式 ]:
C15H16O2
[ 分子量 ]:
228.286
[ 闪点 ]:
192.4±17.8 °C
[ 精确质量 ]:
228.115036
[ PSA ]:
40.46000
[ LogP ]:
3.43
[ 外观性状 ]:
白色至淡棕色片或粉末
[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C
[ 折射率 ]:
1.599
[ 储存条件 ]:
Refrigerator
[ 水溶解性 ]:
<0.1 g/100 mL at 21.5 ºC
双酚aMSDS
双酚a毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SL6300000
- CHEMICAL NAME :
- Phenol, 4,4'-isopropylidenedi-
- CAS REGISTRY NUMBER :
- 80-05-7
- BEILSTEIN REFERENCE NO. :
- 1107700
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 49
- MOLECULAR FORMULA :
- C15-H16-O2
- MOLECULAR WEIGHT :
- 228.31
- WISWESSER LINE NOTATION :
- QR DX1&1&R DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2400 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1700 mg/m3/2H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2500 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Liver - fatty liver degeneration Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2230 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 6500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12 mg/kg/12D-I
- TOXIC EFFECTS :
- Liver - fatty liver degeneration Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 42 gm/kg/8W-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5460 mg/kg/13W-C
- TOXIC EFFECTS :
- Gastrointestinal - other changes Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 31500 mg/kg/9W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased Liver - other changes Blood - other hemolysis with or without anemia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 455 mg/kg/26W-I
- TOXIC EFFECTS :
- Behavioral - alteration of classical conditioning Liver - liver function tests impaired Blood - other changes
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 mg/m3/6H/13W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 47 mg/m3/2H/19W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - urine volume decreased Endocrine - changes in spleen weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 273 gm/kg/13W-C
- TOXIC EFFECTS :
- Liver - other changes Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/m3/2H/41D-I
- TOXIC EFFECTS :
- Liver - fatty liver degeneration Kidney, Ureter, Bladder - other changes Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 31500 mg/kg/9W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in erythrocyte (RBC) count Biochemical - Metabolism (Intermediary) - lipids including transport
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 4550 mg/kg/26W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Endocrine - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 10 gm/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 15 gm/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1275 mg/kg
- SEX/DURATION :
- female 1-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1275 mg/kg
- SEX/DURATION :
- female 1-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1875 mg/kg
- SEX/DURATION :
- female 1-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1275 mg/kg
- SEX/DURATION :
- female 1-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1875 mg/kg
- SEX/DURATION :
- female 1-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - gastrointestinal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 12500 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 7500 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 12500 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- TYPE OF TEST :
- DNA adduct
- TYPE OF TEST :
- DNA adduct
MUTATION DATA
- TYPE OF TEST :
- Micronucleus test
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 200 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 390,21,1997 *** REVIEWS *** TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Shipyard):CL 0.5 ppm (2.8 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 OEL-THAILAND:TWA 0.5 ppm (2.8 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 12845 No. of Facilities: 5427 (estimated) No. of Industries: 82 No. of Occupations: 74 No. of Employees: 71597 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0995 No. of Facilities: 6 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 2180 (estimated) No. of Female Employees: 49 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 12845 No. of Facilities: 5987 (estimated) No. of Industries: 70 No. of Occupations: 78 No. of Employees: 92138 (estimated) No. of Female Employees: 15144 (estimated)
双酚a安全信息
[ 符号 ]:
GHS05, GHS07, GHS08, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H317-H318-H335-H361f-H411
[ 警示性声明 ]:
P261-P273-P280-P305 + P351 + P338
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
Xn:Harmful
[ 风险声明 (欧洲) ]:
R37;R41;R43;R62
[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S46-S39-S36/37
[ 危险品运输编码 ]:
UN 3077 9 / PGIII
[ WGK德国 ]:
2
[ RTECS号 ]:
SL6300000
[ 海关编码 ]:
2907230001
双酚a合成路线
双酚a上下游产品
双酚a上游产品
双酚a下游产品
双酚a制备
由苯酚和丙酮在酸性介质中缩合而得。当以硫酸为催化剂时,酸浓度为72.5-76.3%,反应温度约40℃。反应在搅拌釜中进行,可采用间歇法生产,也可以安排连续生产的装置。产物经中和,离收分离得粗双酚A,用二甲苯-水萃取法精制即得成品。硫酸法需要的设备较少,工艺简单,但产品质量差,原料消耗高,“三废”较多,只适合中小型间歇生产。为了得到质量好的聚合级双酚A,普遍采用的工业制法是以氯化氢气体作催化剂的方法。将丙酮与苯酚混合,用干燥的氯化氢作催化剂在常压下进行反应,反应于50-60℃进行8-9h,气相氯化氢浓度保持在96%以上。反应除生成双酚A外,还生成一些异构体、三羟基或一羟基副产物。这些少量的杂质并不影响用于制造环氧树脂。但用于制造聚碳酸酯时,则必须精制。虎克法工艺是在压力下蒸馏与萃取结晶来精制双酚A,使产品成本降低。原料消耗定额:苯酚940kg/t、丙酮320kg/t、硫酸(98%)500kg/t。
氯化氢法 苯酚和丙酮在氯化氢存在下进行反应制得双酚A。该法在美、日等国家广泛应用。典型工艺是虎克(Hooker)法。过量苯酚及丙酮(配比大于8∶1)与以盐酸饱和的循环物料一起加入反应器,在常压下于50~60℃搅拌反应8~9h。然后将反应产物送氯化氢解吸塔,经汽提自塔顶蒸出氯化氢回收系统,分离氯化氢并循环回反应器。有机相中主要含苯酚,可循环回氯化氢解吸塔。除去酸后的反应混合物,自氯化氢解吸塔排出进苯酚回收塔,过量苯酚自塔顶分离后,循环回收反应器。塔釜粗产品送异构体分离塔,在真空下分离邻、对位异构体并循环回反应器。釜液进双酚A精馏塔,在真空下蒸馏分离焦油状物质。塔顶蒸出的双酚A以溶剂甲苯萃取和重结晶方式精制,分离结晶后母液经蒸馏回收溶剂。双酚a海关
[ 海关编码 ]: 2907230001
[ 中文概述 ]:
2907230001 双酚A〔4,4-异亚丙基联苯酚〕. 增值税率:17.0% 退税率:9.0% 监管条件:无 最低关税:5.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2907230001 4,4'-(propane-2,2-diyl)diphenol VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none Lowest tariff:5.5% General tariff:30.0%
双酚a文献
Biosens. Bioelectron. 74 , 830-5, (2015)
A highly sensitive electrochemical biosensor for the detection of Bisphenol A (BPA) in water has been developed by immobilizing tyrosinase onto a diazonium-functionalized boron doped diamond electrode...
Effects of Endocrine Disruptor Compounds, Alone or in Combination, on Human Macrophage-Like THP-1 Cell Response.PLoS ONE 10 , e0131428, (2015)
The aim of the present study was to evaluate the immunological effects on human macrophages of four endocrine disruptor compounds (EDCs) using the differentiated human THP-1 cell line as a model. We s...
Determination of bisphenols in beverages by mixed-mode solid-phase extraction and liquid chromatography coupled to tandem mass spectrometry.J. Chromatogr. A. 1422 , 230-8, (2015)
Facing growing restrictions on the use of bisphenol A in food contact materials, several bisphenol analogs are arising as major alternatives to replace this chemical in most of its applications. This ...
相关化工产品/化学物质:
推荐生产厂家/供应商:
公司名:南通润丰石油化工有限公司
区域:南通市崇川区
价格:
¥需询单/1kg
¥需询单/1ton
联系人:曹经理
产品详情:双酚A
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥118.0/500g
¥268.0/50mg
联系人:刘佳
产品详情:双酚A
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
产品详情:Bisphenol A
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥980.0/5g
¥需询单/1g
¥需询单/1g
¥需询单/1g
联系人:李先生
产品详情:双酚A
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥30.9/100g
¥87.9/500g
¥51.9/100g
¥37.9/25g
联系人:阿拉丁李高志
产品详情:双酚A
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相关化合物
【双酚a】化源网提供双酚aCAS号80-05-7,双酚aMSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询双酚a上化源网,专业又轻松。>>电脑版:双酚a
标题:双酚a_MSDS_用途_密度_双酚aCAS号【80-05-7】_化源网 地址:https://www.chemsrc.com/amp/cas/80-05-7_329622.html