异丁酸

异丁酸用途

【用途一】
主要用于合成异丁酸酯类产品，如异丁酸甲酯、丙酯、异戊酯、苄酯等，可作为食用香料，也用于制药
【用途二】
GB 2760—1996规定为允许使用的食用香料。主要用以配制奶油、苹果、焦糖、干酪、面包、酵母等香精。
【用途三】
异丁酸没有丁酸重要。用途与正丁酸相似，主要用来生产相应的酯，例如异丁酸甲酯有杏香，异丁酸丙酯有菠萝香味，异丁酸异戊酯有香蕉味，异丁酸辛酯有葡萄味，异丁酸苄酯有草霉香味的茉莉味等，可用作合成香精和溶剂。也用于制造清漆和增塑剂。异丁酸有一些重要的衍生物，工业上实际用于生产异丁腈的中间体，再转化为盐酸异丁脒，它是杀虫剂二嗪农的原料。
【用途四】
用作脂类的溶剂，有机合成中也用于香精、香料的制备和作防腐剂等．皮革脱灰。消毒剂。

异丁酸名称

[ CAS 号 ]:
79-31-2

[ 中文名 ]:
异丁酸

[ 英文名 ]:
Isobutyric acid

[中文别名 ]:

[英文别名 ]:

2-Methylpropionic acid
α-methylpropionic acid
MFCD00002658
Methylpropanoic acid, 2-
Propanoic acid, 2-methyl-
isobutanoic acid
2-methyl-propionic acid
a-Methylpropionic acid
Isopropyl formic acid
4-02-00-00843 (Beilstein Handbook Reference)

异丁酸物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
155.2±8.0 °C at 760 mmHg

[ 熔点 ]:
-47 °C

[ 分子式 ]:
C₄H₈O₂

[ 分子量 ]:
88.105

[ 闪点 ]:
55.6±0.0 °C

[ 精确质量 ]:
88.052429

[ PSA ]:
37.30000

[ LogP ]:
0.59

[ 外观性状 ]:
无色液体,带有特有的气味

[ 蒸汽密度 ]:
3.04 (vs air)

[ 蒸汽压 ]:
1.6±0.6 mmHg at 25°C

[ 折射率 ]:
1.408

[ 储存条件 ]:
包装完整、轻装轻卸,库房通风、远离明火、高温、与氧化剂、碱分开存放

[ 水溶解性 ]:
210 g/L (20 ºC)

异丁酸MSDS

详细MSDS(安全技术说明书)

异丁酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NQ4375000

CHEMICAL NAME :: Isobutyric acid

CAS REGISTRY NUMBER :: 79-31-2

BEILSTEIN REFERENCE NO. :: 0635770

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C4-H8-O2

MOLECULAR WEIGHT :: 88.12

WISWESSER LINE NOTATION :: QVY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 280 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 *** REVIEWS *** TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,100,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4110 No. of Facilities: 93 (estimated) No. of Industries: 4 No. of Occupations: 14 No. of Employees: 5052 (estimated) No. of Female Employees: 652 (estimated)

异丁酸安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H302-H311-H314

[ 警示性声明 ]:
P210-P260-P280-P303 + P361 + P353-P305 + P351 + P338-P370 + P378

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R21/22

[ 安全声明 (欧洲) ]:
S23-S36/37/39

[ 危险品运输编码 ]:
UN 2529 3/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
NQ4375000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
2915600000

异丁酸合成路线

详细合成路线

异丁酸上下游产品

异丁酸上游产品

异丁酸下游产品

异丁酸制备

1.异丁醛直接氧化法：异丁醛与空气或氧气直接进行氧化反应即得。

2.甲基丙烯酸加氢法其反应式如下：

3.制法：

于装有搅拌器，滴液漏斗，温度计的5L反应瓶中，加入52g（0.7mol）异丁醇（2），10%碳酸钠水溶液150mL，冰水浴冷却，控制于10～15℃滴加高锰酸钾142g（0.9mol）溶于2.75L水配成的溶液，约3～4h加完。加完后室温放置过夜^①。将析出的二氧化锰滤去，滤液减压浓缩至约150mL，冷后用50%的硫酸酸化至PH2～3。乙醚提取（50mL×3），无水硫酸镁干燥，蒸去乙醚，蒸馏收集150～158℃的馏分。将此馏分重蒸一次，收集153～155℃的馏分，得异丁酸（1）^②45g，收率76%。注：①应使高锰酸钾的紫色褪去。若不褪色，可继续搅拌更长时间，或加入少量甲醇使紫色消失。②也可用重铬酸钾氧化异丁醇来制备。二甲基丙二酸加热至190℃，失去一个分子二氧化碳可生成异丁酸。

异丁酸海关

[ 海关编码 ]: 2915600000

[ 中文概述 ]:
HS:2915600000 丁酸、戊酸及其盐和酯增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2915600000 butanoic acids and pentanoic acids and their salts and esters VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

异丁酸文献

Combined effects of nutrients and temperature on the production of fermentative aromas by Saccharomyces cerevisiae during wine fermentation.

Appl. Microbiol. Biotechnol. 99(5) , 2291-304, (2015)

Volatile compounds produced by yeast during fermentation greatly influence the organoleptic qualities of wine. We developed a model to predict the combined effects of initial nitrogen and phytosterol ...

Olfactometry Profiles and Quantitation of Volatile Sulfur Compounds of Swiss Tilsit Cheeses.

J. Agric. Food Chem. 63 , 7511-21, (2015)

To establish the odor profiles of three differently fabricated commercial Swiss Tilsit cheeses, analyses were conducted using headspace solid-phase microextraction gas chromatography-mass spectrometry...

GC/MS method for determining carbon isotope enrichment and concentration of underivatized short-chain fatty acids by direct aqueous solution injection of biogas digester samples.

Talanta 143 , 56-63, (2015)

In anaerobic digestion of organic matter, several metabolic pathways are involved during the simultaneous production and consumption of short-chain fatty acids (SCFA) in general and acetate in particu...

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异丁酸