异丁醛

异丁醛用途

【用途一】
用于制橡胶硫化促进剂和防老剂、异丁酸等
【用途二】
GB 2760一1996规定为允许使用的食用香料。主要用以配制焦糖、香蕉和各种水果型香精。
【用途三】
异丁醛的用途不如正丁醛广泛。工业上主要是加氢生产异丁醇。异丁醇在某些方面可作为正丁醇的代用品。异丁醛与甲醛经加成反应生成羟基三甲基乙醛，再加氢生成新戊二醇，用作清漆、树脂、纤维和润滑剂的原料；异丁醛与尿素反应制得的肥料能缓慢释放出氮；此外，也用作氨基酸、维生素等药物的中间体。羰基合成法按比例同时得到正丁醛和异丁醛，消费平衡的情况仍然是异丁醛供过于求，极大量异丁醛被当作燃料利用。
【用途四】
合成泛酸、缬氨酸、亮氨酸、纤维素酯、香料、增塑剂、树脂及汽油添加剂。也用于制造硫化促进剂和防老剂、异丁酸等。

异丁醛名称

[ CAS 号 ]:
78-84-2

[ 中文名 ]:
异丁醛

[ 英文名 ]:
Isobutyraldehyde

[中文别名 ]:

[英文别名 ]:

Isobutaldehyde
isobutyral
EINECS 201-149-6
Isobutyraldehyde
iso-C3H7CHO
α-Methylpropionaldehyde
FEMA 2220
1-keto-2-methylpropane
2-Methylpropanal
isobutyric

异丁醛物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
67.1±8.0 °C at 760 mmHg

[ 熔点 ]:
−65 °C(lit.)

[ 分子式 ]:
C₄H₈O

[ 分子量 ]:
72.106

[ 闪点 ]:
-18.9±0.0 °C

[ 精确质量 ]:
72.057518

[ PSA ]:
17.07000

[ LogP ]:
0.72

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
2.5 (vs air)

[ 蒸汽压 ]:
147.4±0.1 mmHg at 25°C

[ 折射率 ]:
1.367

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Refrigerate. Highly flammable. Incompatible with strong oxidizing agents, strong bases, strong acids, strong reducing agents.

[ 水溶解性 ]:
75 g/L (20 ºC)

异丁醛MSDS

详细MSDS(安全技术说明书)

异丁醛毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NQ4025000

CHEMICAL NAME :: Isobutyraldehyde

CAS REGISTRY NUMBER :: 78-84-2

LAST UPDATED :: 199806

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C4-H8-O

MOLECULAR WEIGHT :: 72.12

WISWESSER LINE NOTATION :: VHY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/3/1971 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 960 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Gastrointestinal - necrotic changes Blood - hemorrhage

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(5),104,1972

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 10,61,1954

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39500 mg/m3/2H

TOXIC EFFECTS :: Behavioral - excitement Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - pleural thickening

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(5),104,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 7130 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 10,61,1954 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84782 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 705 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84782 No. of Facilities: 32 (estimated) No. of Industries: 3 No. of Occupations: 2 No. of Employees: 4114 (estimated) No. of Female Employees: 655 (estimated)

异丁醛安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319

[ 警示性声明 ]:
P210-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R22

[ 安全声明 (欧洲) ]:
S16-S36/37-S9-S33-S29

[ 危险品运输编码 ]:
UN 2045 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
NQ4025000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2912190090

异丁醛合成路线

详细合成路线

异丁醛上下游产品

异丁醛上游产品

异丁醛下游产品

异丁醛制备

1.工业方法主要是羰基合成法:以丙烯、一氧化碳和氢气微原料，经羰基合成成得正丁醛与异丁醛的混合物，再经分馏而得成品。采用不同的工艺方法，所得正丁醛和异丁醛的比例也不同。高压法正异比为3-4：1，低压法的正异比为8-10：1。

异丁醛海关

[ 海关编码 ]: 2912190090

[ 中文概述 ]:
HS: 2912190090. 其他无环醛（不含其他含氧基）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 四聚甲醛报明外观

[ Summary ]:
2912190090 acyclic aldehydes without other oxygen function。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

异丁醛文献

Comparison of Aroma-Active Volatiles in Oolong Tea Infusions Using GC-Olfactometry, GC-FPD, and GC-MS.

J. Agric. Food Chem. 63 , 7499-510, (2015)

The aroma profile of oolong tea infusions (Dongdingwulong, DDWL; Tieguanyin, TGY; Dahongpao, DHP) were investigated in this study. Gas chromatography-olfactometry (GC-O) with the method of aroma inten...

Orientation to determine quality attributes of flavoring excipients containing volatile molecules.

J. Pharm. Biomed. Anal. 110 , 20-6, (2015)

Pharmaceutical excipients containing volatile odor-active molecules can be used in pharmaceutical development to increase patients' compliance. However, capturing the molecular composition of these od...

Alkaline comet assay in liver and stomach, and micronucleus assay in bone marrow, from rats treated with 2-acetylaminofluorene, azidothymidine, cisplatin, or isobutyraldehyde.

Mutat. Res. Genet. Toxicol. Environ. Mutagen. 786-788 , 77-86, (2015)

As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM) initiative international validation study of the in vivo rat alkaline comet assay (comet assay), we examined the abili...

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异丁醛