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硝酸芬替康唑

硝酸芬替康唑用途

Fenticonazole硝酸盐是抗真菌化合物。

硝酸芬替康唑名称

[ CAS 号 ]:
73151-29-8

[ 中文名 ]:
硝酸芬替康唑

[ 英文名 ]:
Fenticonazole nitrate

[中文别名 ]:

硝酸芬康唑

[英文别名 ]:

Lomexin
EINECS 277-302-6
MFCD00941391
Falvin
REC 15/1476
Fenticonazole nitrate (USAN)
Fenticonazole (Nitrate)
Fenticonazole mononitrate

硝酸芬替康唑生物活性

[ 描述 ]:

Fenticonazole硝酸盐是抗真菌化合物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 真菌

研究领域 >> 感染

[参考文献]

[1]. Fernandez-Alba, J., et al., Fenticonazole nitrate for treatment of vulvovaginitis: efficacy, safety, and tolerability of 1-gram ovules, administered as ultra-short 2-day regimen. J Chemother, 2004. 16(2): p. 179-86.

[相关活性小分子]

硝酸芬替康唑物理化学性质

[ 密度 ]:
1.26g/cm3

[ 沸点 ]:
637.2ºC at 760 mmHg

[ 熔点 ]:
135-137ºC

[ 分子式 ]:
C₂₄H₂₁Cl₂N₃O₄S

[ 分子量 ]:
518.412

[ 闪点 ]:
339.2ºC

[ 精确质量 ]:
517.062988

[ PSA ]:
118.40000

[ LogP ]:
7.47470

[ 外观性状 ]:
白色-类白色晶体-粉末

[ 折射率 ]:
1.632

[ 储存条件 ]:
Refrigerator

硝酸芬替康唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI4780000

CHEMICAL NAME :: Imidazole, 1-(2,4-dichloro-beta-(p-(phenylthio)benzyloxy)pheneth yl)-, nitrate

CAS REGISTRY NUMBER :: 73151-29-8

LAST UPDATED :: 199403

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C24-H20-Cl2-N2-O-S.H-N-O3

MOLECULAR WEIGHT :: 518.44

WISWESSER LINE NOTATION :: T5N CNJ A1YO1R DSR&&R BG DG &..H..N-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,2145,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 309 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,2145,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >750 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,2145,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,2145,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1191 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,2145,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,2145,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,2145,1981

硝酸芬替康唑安全信息

[ 危害码 (欧洲) ]:
Xi,Xn

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .

[ 安全声明 (欧洲) ]:
S26

[ 海关编码 ]:
2942000000

硝酸芬替康唑制备

2,4-二氯苯-α-氯乙酮经氢硼化钠还原后，先和咪唑缩合，再和4-氯甲基二苯硫醚缩合，即得芬康唑。

硝酸芬替康唑海关

[ 海关编码 ]: 2942000000

硝酸芬替康唑文献

In vitro activity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates of Candida albicans and Candida spp.

Mycopathologia 118(1) , 15-21, (1992)

The in vitro activity of several new imidazoles, cloconazole, sulconazole, butoconazole, isoconazole and fenticonazole, were compared with those of amphothericin B, flucytosine, and three azoles: econ...

Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes.

Antimicrob. Agents Chemother. 53 , 2181-4, (2009)

The activity of fenticonazole was studied against 260 West and Southeast European vulvovaginal candidiasis isolates, and low MICs were displayed. Fenticonazole was assessed by European Committee on An...

Single dose therapy of vaginal candidiasis: a comparative trial of fenticonazole vaginal ovules versus clotrimazole vaginal tablets.

Curr. Med. Res. Opin. 12(2) , 114-20, (1990)

An open, randomized comparative clinical trial was performed in 153 patients suffering from symptomatic vaginal candidiasis confirmed by mycological tests. Patients were allocated at random into two g...

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