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3-[4-[[2,4-二(三氟甲基)苄基]氧基]-3-甲氧基苯基]-2-氰基-N-(5-三氟甲基-[1,3,4]噻二唑-2-基)丙烯酰胺

用途

XCT-790是雌激素相关受体（ERR）α反向激动剂，能诱导化疗抗性的癌细胞死亡。

名称

[ CAS 号 ]:
725247-18-7

[ 中文名 ]:
3-[4-[[2,4-二(三氟甲基)苄基]氧基]-3-甲氧基苯基]-2-氰基-N-(5-三氟甲基-[1,3,4]噻二唑-2-基)丙烯酰胺

[ 英文名 ]:
XCT 790

[英文别名 ]:

XCT790
hms3263n08

生物活性

[ 描述 ]:

XCT-790是雌激素相关受体(ERR)α反向激动剂,能诱导化疗抗性的癌细胞死亡。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 癌症

[参考文献]

[1]. Wu F, et al. Estrogen-related receptor alpha (ERRalpha) inverse agonist XCT-790 induces cell death in chemotherapeutic resistant cancer cells. Chem Biol Interact. 2009 Oct 7;181(2):236-42.

[2]. Busch BB, et al. Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha. J Med Chem. 2004 Nov 4;47(23):5593-6.

[相关活性小分子]

物理化学性质

[ 密度 ]:
1.544g/cm3

[ 分子式 ]:
C₂₃H₁₃F₉N₄O₃S

[ 分子量 ]:
596.42500

[ 精确质量 ]:
596.05600

[ PSA ]:
125.37000

[ LogP ]:
6.80078

[ 折射率 ]:
1.55

[ 储存条件 ]:
2-8℃

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 危害声明 ]:
H413

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Estrogen-related receptor α is required for efficient human cytomegalovirus replication.

Proc. Natl. Acad. Sci. U. S. A. 111(52) , E5706-15, (2014)

An shRNA-mediated screen of the 48 human nuclear receptor genes identified multiple candidates likely to influence the production of human cytomegalovirus in cultured human fibroblasts, including the ...

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells.

Oncotarget 6 , 14777-95, (2015)

Here, we show that new mitochondrial biogenesis is required for the anchorage independent survival and propagation of cancer stem-like cells (CSCs). More specifically, we used the drug XCT790 as an in...

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