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[5S,12R]-二羟基-[6Z,8E,10E,14Z]-二十碳四烯酸

用途

Leukotriene B4 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

名称

[ CAS 号 ]:
71160-24-2

[ 中文名 ]:
白三烯B4

[ 英文名 ]:
Leukotriene B4

[中文别名 ]:

白[细胞]三烯 b4

[英文别名 ]:

Leukotriene B4
6Z,8E,10E,14Z,5S,12R-diHETE
EINECS 200-578-6
LTB4
Leukotriene B4 Lipid Maps MS Standard
MFCD00135630

生物活性

[ 描述 ]:

Leukotriene B4 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl-Chain

Human Endogenous Metabolite

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
536.4±50.0 °C at 760 mmHg

[ 熔点 ]:
-144.0 °C (lit.)

[ 分子式 ]:
C₂₀H₃₂O₄

[ 分子量 ]:
336.466

[ 闪点 ]:
292.3±26.6 °C

[ 精确质量 ]:
336.230072

[ PSA ]:
77.76000

[ LogP ]:
4.06

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.527

[ 储存条件 ]:
−20°C

安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ 危害码 (欧洲) ]:
F: Flammable;

[ 风险声明 (欧洲) ]:
11

[ 安全声明 (欧洲) ]:
S7-S16

[ 危险品运输编码 ]:
UN 1170 3/PG 2

[ WGK德国 ]:
1

合成路线

详细合成路线

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文献

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production.

Antimicrob. Agents Chemother. 58(8) , 4298-307, (2014)

The accumulation of neutrophils and proinflammatory mediators, such as leukotriene B4 (LTB4), is a classic marker of inflammatory disease. The clearance of apoptotic neutrophils, inhibition of proinfl...

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