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酒石酸溴莫尼定

酒石酸溴莫尼定用途

UK 14,304是_alpha_2-adrenergic receptor (_alpha_2-AR)受体激动剂。

酒石酸溴莫尼定名称

[ CAS 号 ]:
70359-46-5

[ 中文名 ]:
酒石酸溴莫尼定

[ 英文名 ]:
Brimonidine L-tartrate

[中文别名 ]:

[英文别名 ]:

Brimonidine tartrate
MFCD07773086
UK 14,304 (tartrate)

酒石酸溴莫尼定生物活性

[ 描述 ]:

UK 14,304是_alpha_2-adrenergic receptor (_alpha_2-AR)受体激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 其他

[参考文献]

[1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12.

[2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5.

[3]. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804.

[相关活性小分子]

酒石酸溴莫尼定物理化学性质

[ 沸点 ]:
432.6ºC at 760 mmHg

[ 熔点 ]:
207-208ºC (dec.)

[ 分子式 ]:
C₁₅H₁₆BrN₅O₆

[ 分子量 ]:
442.221

[ 闪点 ]:
215.4ºC

[ 精确质量 ]:
441.028381

[ PSA ]:
177.26000

[ 外观性状 ]:
奶油色-淡黄色粉末

[ 储存条件 ]:
-20°C Freezer

酒石酸溴莫尼定MSDS

详细MSDS(安全技术说明书)

酒石酸溴莫尼定安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H335

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P305 + P351 + P338

[ 安全声明 (欧洲) ]:
S36/37

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ 海关编码 ]:
2933990090

酒石酸溴莫尼定海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

酒石酸溴莫尼定文献

Dilute brimonidine to improve patient comfort and subconjunctival hemorrhage after LASIK.

J. Refract. Surg. 29(7) , 469-75, (2013)

To investigate whether dilute brimonidine (0.025%) reduces patient discomfort, subconjunctival hemorrhage, and injection after LASIK without a significant increase in the rate of flap complications or...

Targeted delivery of antiglaucoma drugs to the supraciliary space using microneedles.

Invest. Ophthalmol. Vis. Sci. 55(11) , 7387-97, (2014)

In this work, we tested the hypothesis that highly targeted delivery of antiglaucoma drugs to the supraciliary space by using a hollow microneedle allows dramatic dose sparing of the drug compared to ...

Determinants and characteristics of angle-closure disease in an elderly Chinese population.

Ophthalmic Epidemiol. 22(2) , 109-15, (2015)

To determine factors associated with angle-closure disease, particularly in those with structural or functional damage to the eyes, in an elderly Chinese population.A total of 460 individuals aged ove...

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