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α,α,α,α',α',α'-六氯对二甲苯

用途

Hexachloroparaxylene 可用于猪片形吸虫病的研究。

名称

[ CAS 号 ]:
68-36-0

[ 中文名 ]:
1,4-双(三氯甲基)苯

[ 英文名 ]:
1,4-BIS(TRICHLOROMETHYL)BENZENE

[中文别名 ]:

[英文别名 ]:

EINECS 200-686-3
MFCD00000791
1,4-bis(trichloromethyl)benzene

生物活性

[ 描述 ]:

Hexachloroparaxylene 可用于猪片形吸虫病的研究。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. A D Kabaloev, et al. Hexachloroparaxylene in fascioliasis in swine. Veterinariia. 1968 May;45(5):47.

物理化学性质

[ 密度 ]:
1.628 g/cm3

[ 沸点 ]:
312 °C

[ 熔点 ]:
106-110 °C

[ 分子式 ]:
C₈H₄Cl₆

[ 分子量 ]:
312.83500

[ 闪点 ]:
153ºC

[ 精确质量 ]:
309.84400

[ LogP ]:
5.34000

[ 外观性状 ]:
白色-微浅黄色晶体-粉末

[ 折射率 ]:
1.584

[ 储存条件 ]:
室温，干燥

MSDS

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZE4655000

CHEMICAL NAME :: p-Xylene, alpha,alpha,alpha,alpha',alpha',alpha'-hexachloro-

CAS REGISTRY NUMBER :: 68-36-0

BEILSTEIN REFERENCE NO. :: 2051282

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C8-H4-Cl6

MOLECULAR WEIGHT :: 312.82

WISWESSER LINE NOTATION :: GXGGR DXGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 21,34,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg/10D-I

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

REFERENCE :: ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 32,107,1986 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2330 mg/kg

SEX/DURATION :: male 26 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 21,34,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2330 mg/kg

SEX/DURATION :: female 26 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 21,34,1982 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3;Skin JAN 1993

安全信息

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S45-S36/37/39-S26

[ RTECS号 ]:
ZE4655000

[ 海关编码 ]:
2903999090

合成路线

上下游产品

上游产品

下游产品

制备

以混二甲苯为原料，先用98%硫酸磺化，使间二甲苯生成间二甲苯磺酸盐。从磺化反应物中分离出含邻、对二甲苯的油层，水洗、干燥，减压蒸馏出邻、对二甲苯。间二甲苯磺酸盐经水解可得副产品间二甲苯。由邻、对二甲苯经氯化即得1，4-双（三氯甲基）苯：在反应锅中投入邻、对二甲苯，再加入过氧化苯甲酰和三乙醇胺。加热到70℃后，在光照射下导入氯气，于70-80℃反应6h，再升温至100-120℃继续反应，至反应液相对密度达到1.560-1.580（65℃），即为反应终点，停止通氯，减压脱除余氯。降温至5℃，过滤，洗涤得粗品，重结晶，活性炭脱色得成品。

海关

[ 海关编码 ]: 2903999090

[ 中文概述 ]:
2903999090 其他芳烃卤化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%