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茶丙洛尔

茶丙洛尔用途

Teoprolol 是一种 β-adrenergic 受体阻滞剂。

茶丙洛尔名称

[ CAS 号 ]:
65184-10-3

[ 中文名 ]:
茶丙洛尔

[ 英文名 ]:
Teoprolol

[英文别名 ]:

Teoprololum [INN-Latin]
Teoprolol
EINECS 265-600-9
D-13,312
Teoprololum

茶丙洛尔生物活性

[ 描述 ]:

Teoprolol 是一种 β-adrenergic 受体阻滞剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 其他

[参考文献]

[1]. S. D. Yuzhakov, et al. Structure-activity relationships in β-adrenoblockers. Pharmaceutical Chemistry Journal. May 1991, Volume 25, Issue 5, pp 283-295

[相关活性小分子]

茶丙洛尔物理化学性质

[ 密度 ]:
1.37g/cm3

[ 沸点 ]:
747.6ºC at 760 mmHg

[ 分子式 ]:
C₂₃H₃₀N₆O₄

[ 分子量 ]:
454.52200

[ 闪点 ]:
405.9ºC

[ 精确质量 ]:
454.23300

[ PSA ]:
119.10000

[ LogP ]:
1.42240

[ 折射率 ]:
1.665

[ 储存条件 ]:
2-8℃

茶丙洛尔毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO8437700

CHEMICAL NAME :: 1H-Purine-2,6-dione, 3,7-dihydro-7-(3-((2-hydroxy-3-((2-methyl-1H-indol-4- yl)oxy)propyl) amino)butyl)-1,3-dimethyl-

CAS REGISTRY NUMBER :: 65184-10-3

BEILSTEIN REFERENCE NO. :: 1234202

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C23-H30-N6-O4

MOLECULAR WEIGHT :: 454.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 38 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982