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对氨基水杨酸

对氨基水杨酸用途

4-Aminosalicylic acid 是具有口服活性的抗生素,可用于肺结核病的研究。

对氨基水杨酸名称

[ CAS 号 ]:
65-49-6

[ 中文名 ]:
4-氨基水杨酸

[ 英文名 ]:
4-aminosalicylic acid

[中文别名 ]:

[英文别名 ]:

PAS
4-Asa
Bactylan
Pasalon-rakeet
Aminox
Tubersan
para-amino salicylic acid
Salvis
Paracipan
4-Amino-2-hydroxybenzoic acid

对氨基水杨酸生物活性

[ 描述 ]:

4-Aminosalicylic acid 是具有口服活性的抗生素,可用于肺结核病的研究。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Vânia André, et al. Crystal Forms of the Antibiotic 4-Aminosalicylic Acid: Solvates and Molecular Salts with Dioxane, Morpholine, and Piperazine. Cryst. Growth Des. 2009, 9, 12, 5108-5116.

对氨基水杨酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
380.8±32.0 °C at 760 mmHg

[ 熔点 ]:
135-145 °C(lit.)

[ 分子式 ]:
C₇H₇NO₃

[ 分子量 ]:
153.135

[ 闪点 ]:
184.1±25.1 °C

[ 精确质量 ]:
153.042587

[ PSA ]:
83.55000

[ LogP ]:
1.14

[ 外观性状 ]:
微小的晶体，无气味的,或有淡醋的气味

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.691

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
2 g/L (20 ºC)

对氨基水杨酸MSDS

对氨基水杨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO1225000

CHEMICAL NAME :: Salicylic acid, 4-amino-

CAS REGISTRY NUMBER :: 65-49-6

BEILSTEIN REFERENCE NO. :: 0473071

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C7-H7-N-O3

MOLECULAR WEIGHT :: 153.15

WISWESSER LINE NOTATION :: ZR CQ DVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3898 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - mouse Mammary gland

DOSE/DURATION :: 2 mmol/L/24H (Continuous)

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 5,141,1980 *** REVIEWS *** TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965

对氨基水杨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39-S45-S53

[ 危险品运输编码 ]:
UN 1789 8/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
VO1225000

[ 海关编码 ]:
29225000

对氨基水杨酸合成路线

对氨基水杨酸上下游产品

对氨基水杨酸上游产品

对氨基水杨酸下游产品

对氨基水杨酸制备

1.由间氨基酚经羟化而得。将水、间氨基酚和碳酸氢钠依次投入反应罐内，通入二氧化碳置换空气后，密闭升温至110±1℃，罐内压力保持0.6-0.8MPa反应6h，冷却至-5℃，加亚硫酸钠，过滤，水洗，合并洗滤液供酸化用。滤饼为间氨基酚回收物，套用。将上述洗滤液升温至10-15℃，用30-40%硫酸中和至pH为6.4-7.0，加入适量的亚硫酸钠与硫化钠溶液，经树脂脱色后，于30℃用30-40%硫酸调节至pH为3- 3.5，放置，甩滤，水洗至硫酸根合格，甩干得对氨基水杨酸。从苯乙酸出发也可以合成得到对氨基水杨酸。先使苯乙酸在浓硫酸和浓硝酸中在60℃下硝化，然后倾入冰水中，过滤析出2,4-二硝基苯乙酸[643-43-6]。硝化产率95%。将得到的产物加入10倍甲醇中，均匀混合后，通入干燥的氯化氢，加热至沸，冷却后析出2,4-二硝基苯乙酸甲酯晶体[58605-12-2]。酯化产率为80%。将酯化物溶解于热甲醇中，加入亚硝酸丁酯，再加入甲醇钠，静置数小时直至完全析出深红色沉淀物，分离沉淀物得中间产物。将其溶于稀氢氧化钾溶液中，加入盐酸酸化，使呈酸性。逸出二氧化碳气体，析出4-硝基-2-羟基苯腈。产率为80%，将此腈化物与水、浓硫酸、冰醋酸混合加热至沸，即可析出4-硝基水杨酸[619-19-2]。将4-硝基水杨酸溶解于25%碳酸钠溶液中，加入硫酸亚铁水溶液，再加适量的碳酸钠溶液，加热至沸，分离析出铁盐。过滤，滤液用乙酸调至pH=3,4-氨基水杨酸则析出。再过滤干燥，即得产品。工业品对氨基水杨酸含量大于70%，氯化物小于50ppm，硫酸根小于500ppm。

2.结构Ⅰ聚芳砜的制备　在反应釜中加入等摩尔比的二苯醚二磺酰氯和联苯，以硝基苯作为溶剂，三氯化铁为催化剂，在130℃反应20h左右，直到反应物特性黏度达到0.66dL/g以上时终止反应。物料倾入甲醇或丙酮中，捣碎，离析出固体树脂，经洗涤、干燥、造粒即得产品。聚合反应式如下：

3.结构Ⅱ聚芳砜的制备　以双酚钠盐与4,4'-双(4-氯苯基磺酰基)联苯为原料，用环丁砜作溶剂，于220℃缩聚而成。缩聚反应可采用两步法，即先制成双酚钠盐后再缩聚。也可采用一步法，即将等摩尔比的双酚S、4,4'-双(4-氯苯基磺酰基)联苯及一定量的环丁砜溶剂和脱水剂二甲苯置于反应釜中，加热熔解，在低于80℃下加NaOH（2倍摩尔双酚S），然后升温脱水，再蒸出二甲苯，将釜温升至220℃进行缩聚反应。当物料达到规定黏度时，加入一定量环丁砜稀释之，降温，停止反应，离析出聚合物，经水煮、过滤、干燥得粉状聚芳砜。

对氨基水杨酸海关

[ 海关编码 ]: 29225000

对氨基水杨酸文献

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