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Phomopsin A

Phomopsin A用途

Phomopsin A 是一种从真菌 Phomopsis leptostomiformis 分离的环状六肽霉菌毒素。Phomopsin A 是放射性标记的长春新碱与微管蛋白结合的非竞争性抑制剂。

Phomopsin A名称

[ CAS 号 ]:
64925-80-0

[ 中文名 ]:
噬菌素A

[ 英文名 ]:
Phomopsin A

[英文别名 ]:

phomopsin a from phomopsis leptostromiformis
phomopsin
PMSA

Phomopsin A生物活性

[ 描述 ]:

Phomopsin A 是一种从真菌 Phomopsis leptostomiformis 分离的环状六肽霉菌毒素。Phomopsin A 是放射性标记的长春新碱与微管蛋白结合的非竞争性抑制剂。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白

信号通路 >> 细胞骨架 >> 微管/微管蛋白

[参考文献]

[1]. Hamel E, et al. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. Pharmacol Ther. 1992;55(1):31-51.

Phomopsin A物理化学性质

[ 密度 ]:
1.48g/cm3

[ 沸点 ]:
1188.2ºC at 760 mmHg

[ 分子式 ]:
C₃₆H₄₅ClN₆O₁₂

[ 分子量 ]:
789.22800

[ 闪点 ]:
672.4ºC

[ 精确质量 ]:
788.27800

[ PSA ]:
273.03000

[ LogP ]:
2.27850

[ 折射率 ]:
1.655

[ 储存条件 ]:
2-8°C，密封，干燥

Phomopsin A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SY2593000

CHEMICAL NAME :: Phomopsin A

CAS REGISTRY NUMBER :: 64925-80-0

LAST UPDATED :: 199801

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 10 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 1 mg/kg/1W-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Liver - other changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 1 mg/kg/4W-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Liver - jaundice (or hyperbilirubinemia) hepatocellular

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 150 ug/kg

SEX/DURATION :: female 6-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 400 ug/kg

SEX/DURATION :: female 6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 mg/L

REFERENCE :: CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 46,79,1986

Phomopsin A安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
20/21/22-40