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香草酸乙酯

香草酸乙酯用途

Ethyl Vanillate 是一种杀菌剂。Ethyl Vanillate 抑制 17β-HSD2,其 IC50 为 1.3 µM。

香草酸乙酯名称

[ CAS 号 ]:
617-05-0

[ 中文名 ]:
香草酸乙酯

[ 英文名 ]:
Ethyl vanillate

[中文别名 ]:

[英文别名 ]:

3-methoxy-4-hydroxybenzoic acid ethyl ester
Ethyl vanillate
Ethyl 4-hydroxy-3-methoxybenzoate
EINECS 210-503-9
Benzoic acid,4-hydroxy-3-methoxy-,ethyl ester
Benzoic acid, 4-hydroxy-3-methoxy-, ethyl ester
4-Hydroxy-3-methoxybenzoic acid ethyl ester
3-methoxy-4-hydroxy-ethyl benzoate
VANILLIC ACID,ETHYL ESTER
Ethyl-4-hydroxy-3-methoxybenzolcarboxylat

香草酸乙酯生物活性

[ 描述 ]:

Ethyl Vanillate 是一种杀菌剂。Ethyl Vanillate 抑制 17β-HSD2,其 IC50 为 1.3 µM。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[ 靶点 ]

IC50: 1.3 µM (17β-HSD2)[1]

[参考文献]

[1]. Engeli RT, et al. Interference of Paraben Compounds with Estrogen Metabolism by Inhibition of 17β-Hydroxysteroid Dehydrogenases. Int J Mol Sci. 2017 Sep 19;18(9). pii: E2007.

[2]. COHEN R, et al. Four new fungicides for Coccidioides immitis: 1. Sodium caprylate. 2. Ethyl vanillate 3. Fradicin. 4. Thiolutin. Arch Pediatr. 1951 Jun;68(6):259-64.

香草酸乙酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
292.0±0.0 °C at 760 mmHg

[ 熔点 ]:
43-45°C

[ 分子式 ]:
C₁₀H₁₂O₄

[ 分子量 ]:
196.200

[ 闪点 ]:
122.4±15.8 °C

[ 精确质量 ]:
196.073563

[ PSA ]:
55.76000

[ LogP ]:
2.07

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.528

[ 储存条件 ]:
室温

香草酸乙酯MSDS

香草酸乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YW5425000

CHEMICAL NAME :: Vanillic acid, ethyl ester

CAS REGISTRY NUMBER :: 617-05-0

BEILSTEIN REFERENCE NO. :: 2100025

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H12-O4

MOLECULAR WEIGHT :: 196.22

WISWESSER LINE NOTATION :: 2OVR DQ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 1,138,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#06395

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 1,138,1955

香草酸乙酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
YW5425000

[ 海关编码 ]:
2918990090

香草酸乙酯合成路线

香草酸乙酯上下游产品

香草酸乙酯上游产品

香草酸乙酯下游产品

香草酸乙酯海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

香草酸乙酯文献

Verifying the botanical authenticity of commercial tannins through sugars and simple phenols profiles.

Food Chem. 206 , 274-83, (2016)

Commercial tannins from several botanical sources and with different chemical and technological characteristics are used in the food and winemaking industries. Different ways to check their botanical ...

Hydro- and solvothermolysis of kraft lignin for maximizing production of monomeric aromatic chemicals.

Bioresour. Technol. 203 , 142-9, (2016)

The hydro-/solvothermolysis of kraft lignin using water and ethanol as a solvent were investigated in this study. The effect of the water-to-ethanol ratio on the yields of monomeric aromatic chemicals...

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