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阿糖胸苷

阿糖胸苷用途

胸腺嘧啶1-β-D-阿拉伯呋喃糖苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

阿糖胸苷名称

[ CAS 号 ]:
605-23-2

[ 中文名 ]:
1-β-D-阿拉伯呋喃糖苷胸腺嘧啶

[ 英文名 ]:
Thymine-beta-D-arabinofuranoside

[中文别名 ]:

[英文别名 ]:

Thymine arabinofuranoside
Thymine, 1-β-D-arabinofuranosyl-
spongothymidine
thymine arabinoside
ARABINOFURANOSYL-5-METHYLURACIL
EINECS 210-083-7
MFCD00065474
ARA-T
1-B-D-Arabinofuranosylthymine
spongothymidin

阿糖胸苷生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

研究领域 >> 其他

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

阿糖胸苷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 分子式 ]:
C₁₀H₁₄N₂O₆

[ 分子量 ]:
258.23

[ 精确质量 ]:
258.085175

[ PSA ]:
124.78000

[ LogP ]:
-1.02

[ 外观性状 ]:
粉末

[ 折射率 ]:
1.619

[ 储存条件 ]:
2-8°C

阿糖胸苷MSDS

阿糖胸苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XP2100200

CHEMICAL NAME :: Thymine, 1-beta-D-arabinofuranosyl-

CAS REGISTRY NUMBER :: 605-23-2

BEILSTEIN REFERENCE NO. :: 0090166

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H14-N2-O6

MOLECULAR WEIGHT :: 258.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 7100 ug/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 23,141,1978

阿糖胸苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
XP2100200

阿糖胸苷合成路线

阿糖胸苷上下游产品

阿糖胸苷上游产品

阿糖胸苷下游产品

阿糖胸苷文献

Image guided drug release from pH-sensitive Ion channel-functionalized stealth liposomes into an in vivo glioblastoma model.

Nanomedicine: Nanotechnology, Biology, and Medicine 11 , 1345-54, (2015)

Liposomal drug delivery vehicles are promising nanomedicine tools for bringing cytotoxic drugs to cancerous tissues selectively. However, the triggered cargo release from liposomes in response to a ta...

Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade.

Sci. Transl. Med. 7 , 315ra188, (2015)

Targeted drug delivery with antibody-drug conjugates such as the HER2-directed ado-trastuzumab emtansine (T-DM1) has emerged as a powerful strategy for cancer therapy. We show that T-DM1 is particular...

iTRAQ-Based Quantitative Proteomic Analysis of Tear Fluid in a Rat Penetrating Keratoplasty Model With Acute Corneal Allograft Rejection.

Invest. Ophthalmol. Vis. Sci. 56 , 4117-24, (2015)

This study aimed to develop a greater understanding of the mechanisms underlying acute corneal allograft rejection by identifying differentially expressed tear proteins at defined stages and discoveri...

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