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1α,25-二羟维生素 D2

1α,25-二羟维生素 D2用途

Ercalcitriol (1α,25-Dihydroxy Vitamin D2)是维生素D2活性代谢物。

1α,25-二羟维生素 D2名称

[ CAS 号 ]:
60133-18-8

[ 中文名 ]:
25-二羟基维生素D2

[ 英文名 ]:
1-α,25-Dihydroxyvitamin D2

[中文别名 ]:

[英文别名 ]:

1α,25-dihydroxyergocalciferol
1alpha,25-dihydroxyvitamin D2
1α,25-Dihydroxy Vitamin D2
1α,25-Dihydroxycalciferol
Ercalcitriol

1α,25-二羟维生素 D2生物活性

[ 描述 ]:

Ercalcitriol (1α,25-Dihydroxy Vitamin D2)是维生素D2活性代谢物。

[ 相关类别 ]:

信号通路 >> 维生素 D 相关 >> VD/VDR

研究领域 >> 代谢疾病

[参考文献]

[1]. Mawer EB, Berry JL, Cundall JP, Still PE, White A.A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).Clin Chim Acta. 1990 Oct 15;190(3):199-209.

[2]. Rambeck et al (1984) Biological activity of 1 alpha,25-dihydroxyergocalciferol in rachitic chicks and in rats. Int.J.Vitamin.Nutr.Res. 54 135.

[3]. Shamik J. Parikh, Marni Edelman, Gabriel I. Uwaifo et al. The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults. The Journal of Clinical Endocrinology & Metabolism March 1, 2004 vol. 89 no. 3 1196-1199

[4]. Daniel W. Coyne, Marvin Grieff, Shubhada N. Ahya et al. Differential effects of acute administration of 19-Nor-1,25-dihydroxy-vitamin D2 and 1,25-dihydroxy-vitamin D3 on serum calcium and phosphorus in hemodialysis patients. American Journal of Kidney Diseases. December 2002,Volume 40, Issue 6 , Pages 1283-1288

[相关活性小分子]

1α,25-二羟维生素 D2物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
577.7±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₈H₄₄O₃

[ 分子量 ]:
428.647

[ 闪点 ]:
242.5±24.7 °C

[ 精确质量 ]:
428.329041

[ PSA ]:
60.69000

[ LogP ]:
6.15

[ 蒸汽压 ]:
0.0±3.6 mmHg at 25°C

[ 折射率 ]:
1.554

[ 储存条件 ]:
−20°C

1α,25-二羟维生素 D2MSDS

1α,25-二羟维生素 D2安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25;R63

[ 安全声明 (欧洲) ]:
36/37-45

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

1α,25-二羟维生素 D2合成路线

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1α,25-二羟维生素 D2文献

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J. Sci. Ind. Res. 65(10) , 808, (2006)

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