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4-肉桂苯酚

4-肉桂苯酚用途

4-异丙基苯酚是聚碳酸酯链终止剂。4-异丙基苯酚广泛用作聚碳酸酯塑料、表面活性剂、杀菌剂和防腐剂的材料。4-异丙基苯酚还诱导小鼠脂肪细胞中的脂质积累[1][2][3]。

4-肉桂苯酚名称

[ CAS 号 ]:
599-64-4

[ 中文名 ]:
4-肉桂苯酚

[ 英文名 ]:
4-cumylphenol

[中文别名 ]:

[英文别名 ]:

P-CUMYLPHENOL
AURORA 4778
paracumilphenol
PARA-CUMYLPHENOL
PCP
Cumyl phenol
EINECS 209-968-0
MFCD00002365

4-肉桂苯酚生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

4-异丙基苯酚(1、5、10、20、40µM；6天)增加3个T3-L1细胞中的脂质积累[3]。细胞活力测定[3]细胞系：3个T3-L1细胞浓度：1、5、10、20、40µM培养时间：6天结果：增加脂质积累,在10µM时达到峰值,增加204%。

[参考文献]

[1]. Yue W, et al. Biodegradation of bisphenol-A polycarbonate plastic by Pseudoxanthomonas sp. strain NyZ600. J Hazard Mater. 2021 Aug 15;416:125775.

[2]. Chiha M, et al. Sonolytic degradation of endocrine disrupting chemical 4-cumylphenol in water. Ultrason Sonochem. 2011 Sep;18(5):943-50.

[3]. Ramskov Tetzlaff CN, Svingen T, et al. Bisphenols B, E, F, and S and 4-cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A. Environ Toxicol. 2020 May;35(5):543-552.

4-肉桂苯酚物理化学性质

[ 密度 ]:
1,115 g/cm3

[ 沸点 ]:
335 °C

[ 熔点 ]:
72-75 °C

[ 分子式 ]:
C₁₅H₁₆O

[ 分子量 ]:
212.28700

[ 闪点 ]:
160 °C

[ 精确质量 ]:
212.12000

[ PSA ]:
20.23000

[ LogP ]:
3.71810

[ 外观性状 ]:
白色至灰白色固体

[ 折射率 ]:
1.587

[ 储存条件 ]:
室温，密封，干燥

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents, acid chlorides, acid anhydrides. Combustible.

4-肉桂苯酚MSDS

4-肉桂苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL1942450

CHEMICAL NAME :: Phenol, p-(alpha,alpha-dimethylbenzyl)-

CAS REGISTRY NUMBER :: 599-64-4

BEILSTEIN REFERENCE NO. :: 1870517

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H16-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 335 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 12(12),44,1968

4-肉桂苯酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25-S37/39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
SL1942450

4-肉桂苯酚合成路线

4-肉桂苯酚上下游产品

4-肉桂苯酚上游产品

4-肉桂苯酚下游产品

4-肉桂苯酚制备

一、生产方法简述：由苯酚与α-甲基苯乙烯缩合而得。将苯酚和硫酸加入反应锅，搅拌冷却，滴加α-甲基苯乙烯。用氢氧化钠中和，蒸出未反应的苯酚和α-甲基苯乙烯得粗品，用重结晶精制即得成品。收率90%。

二、用途：用作表面活性剂的原料。对异丙苯基酚与环氧乙烷加成得到非离子型表面活性剂。用作杀菌防霉剂。该品杀菌防霉力强。对矿物油和锭子油的亲和性好，可用作润滑等杀菌防霉剂。与五氯酚相比，毒性要小得多，而且没有刺激气味，也可用于木材的杀菌、防霉。用作树脂的原料。与甲醛制成烷基苯酚树脂，用于涂料、粘合剂等。该品还用作环氧树脂的分子量调节剂、反应性稀释剂、增量剂；与高级脂肪酸、磷酸等生成酯类，用作增塑剂和稳定剂；还用作聚碳酸酯的分子量调节剂。

4-肉桂苯酚文献

Degradation and toxicity reduction of the endocrine disruptors nonylphenol, 4-tert-octylphenol and 4-cumylphenol by the non-ligninolytic fungus Umbelopsis isabellina.

Bioresour. Technol. 200 , 223-9, (2015)

Nonylphenol (NP), 4-tert-octylphenol (4-t-OP) and 4-cumylphenol (4-CP) are pollutants that are known as endocrine disruptors mainly due to their estrogen-mimicking activity. These phenolic substances ...

Occurrence, removal, and fate of progestogens, androgens, estrogens, and phenols in six sewage treatment plants around Dianchi Lake in China.

Environ. Sci. Pollut. Res. Int. 21(22) , 12898-908, (2014)

The occurrence and behavior of endocrine disrupting chemicals (EDCs) in sewage treatment plants (STPs), especially estrogens and phenols, have been closely concerned in previous studies. However, the ...

Double salts of ionic-liquid-based surfactants in microextraction: application of their mixed hemimicelles as novel sorbents in magnetic-assisted micro-dispersive solid-phase extraction for the determination of phenols.

Anal. Bioanal. Chem 407 , 8753-64, (2015)

The use of mixed hemimicelles of ionic liquid (IL)-based surfactants in a magnetic-based micro-dispersive solid-phase extraction (m-μdSPE) approach is described. Not only is the symmetric monocationic...

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