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4-氟苯酚

4-氟苯酚用途

【用途一】
索比尼尔的中间体
【用途二】
用作医药、农药及染料中间体
【用途三】
索比尼尔的中间体。

4-氟苯酚名称

[ CAS 号 ]:
371-41-5

[ 中文名 ]:
4-氟苯酚

[ 英文名 ]:
4-Fluorophenol

[中文别名 ]:

[英文别名 ]:

4-fluoranylphenol
p-Fluorophenol
Phenol, p-fluoro-
Phenol,p-fluoro
MFCD00002316
4-Fluorophenol
phenol,4-fluoro
PARA-FLUOROPHENOL
4-Fluoro-phenol
QR DF

4-氟苯酚物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
183.3±13.0 °C at 760 mmHg

[ 熔点 ]:
43-46 °C(lit.)

[ 分子式 ]:
C₆H₅FO

[ 分子量 ]:
112.102

[ 闪点 ]:
68.3±0.0 °C

[ 精确质量 ]:
112.032440

[ PSA ]:
20.23000

[ LogP ]:
1.77

[ 外观性状 ]:
白色至黄色固体

[ 蒸汽压 ]:
0.6±0.4 mmHg at 25°C

[ 折射率 ]:
1.523

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Flammable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
50 g/L

4-氟苯酚MSDS

4-氟苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL4550000

CHEMICAL NAME :: Phenol, p-fluoro-

CAS REGISTRY NUMBER :: 371-41-5

BEILSTEIN REFERENCE NO. :: 1362752

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C6-H5-F-O

MOLECULAR WEIGHT :: 112.11

WISWESSER LINE NOTATION :: QR DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 312 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,868,1975 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg/25W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 19,413,1959 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 41,43,1990

4-氟苯酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H315-H319-H332-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38;R52/53

[ 安全声明 (欧洲) ]:
S26-S37/39-S61

[ 危险品运输编码 ]:
UN 2928 6.1/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
SL4550000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29081000

4-氟苯酚合成路线

4-氟苯酚上下游产品

4-氟苯酚上游产品

4-氟苯酚下游产品

4-氟苯酚海关

[ 海关编码 ]: 2908199090

[ 中文概述 ]:
HS:2908199090 其他酚及酚醇的仅含卤素取代基的衍生物及其盐增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

4-氟苯酚文献

Atmospheric pressure chemical ionization of fluorinated phenols in atmospheric pressure chemical ionization mass spectrometry, tandem mass spectrometry, and ion mobility spectrometry.

J. Am. Soc. Mass Spectrom. 10(11) , 1157-65, (1999)

Atmospheric pressure chemical ionization (APCI)-mass spectrometry (MS) for fluorinated phenols (C6H5-xFxOH Where x = 0-5) in nitrogen with Cl- as the reagent ion yielded product ions of M Cl- through ...

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.

J. Med. Chem. 48 , 7234-42, (2005)

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspas...

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