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环氧丙酰胺

环氧丙酰胺用途

Glycidamide 是丙烯酰胺的遗传毒性代谢物。Glycidamide 可以与血红蛋白等蛋白质或 DNA 发生反应,并诱导基因毒性作用。

环氧丙酰胺名称

[ CAS 号 ]:
5694-00-8

[ 中文名 ]:
环氧丙酰胺

[ 英文名 ]:
UNII:6G5ELX5XYN

[中文别名 ]:

环氧乙烷-2-羧酰胺

[英文别名 ]:

2-Oxiranecarboxamide
Oxirane-2-carboxamide
UNII:6G5ELX5XYN

环氧丙酰胺生物活性

[ 描述 ]:

Glycidamide 是丙烯酰胺的遗传毒性代谢物。Glycidamide 可以与血红蛋白等蛋白质或 DNA 发生反应,并诱导基因毒性作用。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Besaratinia A, et al. Genotoxicity of acrylamide and glycidamide. J Natl Cancer Inst. 2004 Jul 7;96(13):1023-9.

环氧丙酰胺物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
321.9±31.0 °C at 760 mmHg

[ 熔点 ]:
32-34ºC

[ 分子式 ]:
C₃H₅NO₂

[ 分子量 ]:
87.077

[ 闪点 ]:
240.8±21.2 °C

[ 精确质量 ]:
87.032028

[ PSA ]:
55.62000

[ LogP ]:
-2.21

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.516

[ 储存条件 ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

环氧丙酰胺MSDS

环氧丙酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB3200000

CHEMICAL NAME :: Glycidamide

CAS REGISTRY NUMBER :: 5694-00-8

BEILSTEIN REFERENCE NO. :: 1280744

LAST UPDATED :: 199712

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C3-H5-N-O2

MOLECULAR WEIGHT :: 87.09

WISWESSER LINE NOTATION :: T3OTJ BVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg/8D-I

TOXIC EFFECTS :: Behavioral - alteration of operant conditioning Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 400 mg/kg

SEX/DURATION :: male 8 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 800 mg/kg

SEX/DURATION :: male 8 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 350 mg/kg

SEX/DURATION :: male 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 371,175,1996

环氧丙酰胺安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H317-H319-H335-H350

[ 警示性声明 ]:
P201-P261-P280-P305 + P351 + P338-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
45-46-22-36/37/38-43

[ 安全声明 (欧洲) ]:
53-26-36/37-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
MB3200000

[ 海关编码 ]:
2924299090

环氧丙酰胺合成路线

环氧丙酰胺上下游产品

环氧丙酰胺上游产品

环氧丙酰胺下游产品

环氧丙酰胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

环氧丙酰胺文献

Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure.

PLoS ONE 9(5) , e94904, (2014)

Metabolism of xenobiotics by cytochrome P450s (encoded by the CYP genes) often leads to bio-activation, producing reactive metabolites that interfere with cellular processes and cause DNA damage. In t...

Excretion of 2,3-dihydroxy-propionamide (OH-PA), the hydrolysis product of glycidamide, in human urine after single oral dose of deuterium-labeled acrylamide.

Arch. Toxicol. 85(6) , 601-6, (2011)

A dose of 0.99 mg d(3)-acrylamide (d(3)-AA) (13.2 μg/kg body weight) was ingested by a healthy male volunteer. Urine samples were collected over a period of 46 h after the intake and analyzed for the ...

Induction of sister chromatid exchange by acrylamide and glycidamide in human lymphocytes: role of polymorphisms in detoxification and DNA-repair genes in the genotoxicity of glycidamide.

Mutat. Res. 752(1-2) , 1-7, (2013)

Acrylamide (AA) is a probable human carcinogen generated in carbohydrate-rich foodstuffs upon heating. Glycidamide (GA), formed via epoxidation, presumably mediated by cytochrome P450 2E1, is consider...

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