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甲基异丙基甲酮

甲基异丙基甲酮用途

【用途一】
主要用作染料中间体，并可用于医药、农药、纺织、油漆、选矿等行业
【用途二】
用作溶剂，也用于塑料及有机合成
【用途三】
溶剂。有机合成。塑料工业。

甲基异丙基甲酮名称

[ CAS 号 ]:
563-80-4

[ 中文名 ]:
3-甲基-2-丁酮

[ 英文名 ]:
3-Methyl-2-butanone

[中文别名 ]:

[英文别名 ]:

UN 2397
Methyl-2-butanone
iso-C3H7COCH3
2-Butanone, 3-methyl-
3-Methylbutan-2-on
MFCD00008919
3-Ketoisopentane
2-Acetylpropane
i-propyl methyl ketone
methyl i-propyl ketone

甲基异丙基甲酮物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
78.3±3.0 °C at 760 mmHg

[ 熔点 ]:
−92 °C(lit.)

[ 分子式 ]:
C₅H₁₀O

[ 分子量 ]:
86.132

[ 闪点 ]:
6.1±0.0 °C

[ 精确质量 ]:
86.073166

[ PSA ]:
17.07000

[ LogP ]:
0.72

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽压 ]:
93.3±0.1 mmHg at 25°C

[ 折射率 ]:
1.381

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 水溶解性 ]:
6 g/L (20 ºC)

甲基异丙基甲酮MSDS

甲基异丙基甲酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EL9100000

CHEMICAL NAME :: 2-Butanone, 3-methyl-

CAS REGISTRY NUMBER :: 563-80-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 25

MOLECULAR FORMULA :: C5-H10-O

MOLECULAR WEIGHT :: 86.15

WISWESSER LINE NOTATION :: 1Y1&V1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 148 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5700 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2572 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Gene conversion and mitotic recombination

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 149,339,1985 *** REVIEWS *** ACGIH TLV-TWA 705 mg/m3 (200 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 200 ppm (705 mg/m3) JAN 1993 OEL-BELGIUM:TWA 200 ppm (705 mg/m3) JAN 1993 OEL-DENMARK:TWA 200 ppm (705 mg/m3) JAN 1993 OEL-FINLAND:TWA 200 ppm (700 mg/m3);STEL 250 ppm (875 mg/m3) JAN 1993 OEL-FRANCE:TWA 200 ppm (705 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 200 ppm (705 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 200 ppm (720 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL ISOPROPYL KETONE-air:10H TWA 200 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83768 No. of Facilities: 68 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 1055 (estimated)

甲基异丙基甲酮安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H336

[ 警示性声明 ]:
P210-P261

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable;

[ 风险声明 (欧洲) ]:
R11

[ 安全声明 (欧洲) ]:
S9-S16-S33

[ 危险品运输编码 ]:
UN 2397 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
EL9100000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2914190090

甲基异丙基甲酮合成路线

甲基异丙基甲酮上下游产品

甲基异丙基甲酮上游产品

甲基异丙基甲酮下游产品

甲基异丙基甲酮制备

1.向50-60℃的叔戊醇中滴加等摩尔的溴，制得2，3-二溴异戊烷，然后加水回流3-5h至水解完全，从反应混合物中蒸出粗品3-甲基-2-丁酮，经精制得到成品，收率59%。

2.制法：

于装有搅拌器、温度计、滴液漏斗的1.5L反应瓶中，加入重蒸（沸点范围0.5℃）的2-叔戊醇（2）176.0g（2mol），水浴加热至50～60℃，于21h内滴加溴320g（2mol），加完后继续搅拌反应直至溴的颜色消失。生成三甲基二溴乙烷（3）。向反应瓶中加入540mL水，装上回流冷凝器，加热回流3～5h，直至水解完全。改为蒸馏装置直接蒸馏，至温度升高并无油状物馏出。剩余物继续蒸馏可以得到约380mL恒沸氢溴酸。馏出液用碳酸钠中和至碱性，分出有机层。有机层中加入20g粉状碳酸钾和5mL水，加热回流16h。分出油层，无水氯化钙或无水碳酸钾干燥。置于含2g干燥的碳酸钠的蒸馏瓶中分馏，收集92～94℃的馏分，得微黄色液体化合物（1）102g，收率59%。

甲基异丙基甲酮海关

[ 海关编码 ]: 2914190090

[ 中文概述 ]:
2914190090 其他不含其他含氧基的无环酮。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914190090 other acyclic ketones without other oxygen function。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

甲基异丙基甲酮文献

Anaerobic degradation of sorbic acid by sulfate-reducing and fermenting bacteria: pentanone-2 and isopentanone-2 as byproducts.

Biodegradation 2(1) , 33-41, (1991)

Strictly anaerobic bacteria were enriched and isolated from freshwater sediment sources in the presence and absence of sulfate with sorbic acid as sole source of carbon and energy. Strain WoSo1, a Gra...

Potential anticonvulsants IV: Condensation of isatin with benzoylacetone and isopropyl methyl ketone.

J. Pharm. Sci. 71(9) , 1052-4, (1982)

Time dependence in mixture toxicity with soft electrophiles: 1. Combined effects of selected SN2- and SNAr-reactive agents with a nonpolar narcotic.

Arch. Environ. Contam. Toxicol. 52(3) , 283-93, (2007)

Frequently the toxicity of an organic chemical mixture is close to dose-additive, even when the agents are thought to induce toxicity at different molecular sites of action. These findings appear to c...

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