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6-马来酰亚氨基己酸

6-马来酰亚氨基己酸用途

6-Maleimidocapronic acid 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

6-马来酰亚氨基己酸名称

[ CAS 号 ]:
55750-53-3

[ 中文名 ]:
6-马来酰亚胺基己酸

[ 英文名 ]:
6-Maleimidocapronic acid

[中文别名 ]:

[英文别名 ]:

MFCD00043140
1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-
6-(2,5-dioxopyrrol-1-yl)hexanoic acid

6-马来酰亚氨基己酸生物活性

[ 描述 ]:

6-Maleimidocapronic acid 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl-Chain

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

6-马来酰亚氨基己酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
407.3±28.0 °C at 760 mmHg

[ 熔点 ]:
86-91ºC

[ 分子式 ]:
C₁₀H₁₃NO₄

[ 分子量 ]:
211.214

[ 闪点 ]:
200.1±24.0 °C

[ 精确质量 ]:
211.084457

[ PSA ]:
74.68000

[ LogP ]:
0.71

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.537

[ 储存条件 ]:
2-8°C

6-马来酰亚氨基己酸MSDS

6-马来酰亚氨基己酸安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2925190090

6-马来酰亚氨基己酸合成路线

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6-马来酰亚氨基己酸上游产品

6-马来酰亚氨基己酸下游产品

6-马来酰亚氨基己酸海关

[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

6-马来酰亚氨基己酸文献

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Can. J. Physiol. Pharmacol. 92(12) , 1037-43, (2014)

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