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头孢洛宁

头孢洛宁用途

头孢洛尼是第一代β-内酰胺头孢菌素类抗生素,广泛用于研究包括葡萄球菌在内的革兰氏阳性菌引起的乳腺炎[1][2][3]。

头孢洛宁名称

[ CAS 号 ]:
5575-21-3

[ 中文名 ]:
头孢洛宁水合物

[ 英文名 ]:
Cephalonium

[中文别名 ]:

头孢洛宁

[英文别名 ]:

Cephalonium
Cefalonum
Cefalonio [INN-Spanish]
Cefalonium [INN-Latin]
Cefalonium Hydrate
CEFALONIUM
EINECS 226-948-7

头孢洛宁生物活性

[ 描述 ]:

头孢洛尼是第一代β-内酰胺头孢菌素类抗生素,广泛用于研究包括葡萄球菌在内的革兰氏阳性菌引起的乳腺炎[1][2][3]。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

β-lactam

[参考文献]

[1]. Harada K, et, al. Assessment of the Usefulness of Cefapirin and Cefalonium Disks for Susceptibility Testing of Staphylococcus aureus Isolates from Bovine Mastitis. Antibiotics (Basel). 2020 Apr 21;9(4):197.

[2]. Demon D, et, al. The intramammary efficacy of first generation cephalosporins against Staphylococcus aureus mastitis in mice. Vet Microbiol. 2012 Nov 9;160(1-2):141-50.

[3]. Berry EA, et, al. Effect of an intramammary teat seal and dry cow antibiotic in relation to dry period length on postpartum mastitis. J Dairy Sci. 2007 Feb;90(2):760-5.

头孢洛宁物理化学性质

[ 熔点 ]:
147-150° (dec)

[ 分子式 ]:
C₂₀H₁₈N₄O₅S₂

[ 分子量 ]:
458.51

[ 精确质量 ]:
458.07200

[ PSA ]:
190.05000

[ 储存条件 ]:
2-8°C

头孢洛宁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU2800000

CHEMICAL NAME :: Pyridinium, 4-carbamoyl-1-((2-carboxy-8-oxo-7-(2-(2-thienyl)aceta mido)-5-thia-1-aza- bicyclo(4.2.0)oct-2-en-3-yl)methyl)- hydroxide, inner salt

CAS REGISTRY NUMBER :: 5575-21-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H18-N4-O5-S2

MOLECULAR WEIGHT :: 458.54

WISWESSER LINE NOTATION :: T46 ANV ES GUTJ HVQ CMV1- BT5SJ& G1- AT6KJ DVZ &Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

头孢洛宁安全信息

[ 危害码 (欧洲) ]:
Xn