<生产厂家价格>

ML204

ML204用途

ML204是TRPC4/C5离子通道新型高效抑制剂。

ML204名称

[ CAS 号 ]:
5465-86-1

[ 中文名 ]:
ML204

[ 英文名 ]:
ML204

[英文别名 ]:

Quinoline, 4-methyl-2-(1-piperidinyl)-
4-methyl-2-piperidylquinoline
4-methyl-2-(piperidin-1-yl)quinoline
2-Piperidino-4-methyl-chinolin
ML204
4-Methyl-2-(1-piperidinyl)-quinoline
4-Methyl-2-(1-piperidinyl)quinoline
2-Piperidino-lepidin

ML204生物活性

[ 描述 ]:

ML204是TRPC4/C5离子通道新型高效抑制剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 神经疾病

[参考文献]

[1]. Miller M, et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46.

[2]. Miller MR, et al. Novel Chemical Inhibitor of TRPC4 Channels. Probe Reports from the NIH Molecular Libraries Program [Internet].

[相关活性小分子]

辣椒碱 | 辣椒平 | 5-(N-乙基-N-异丙基)阿米洛利 | 氯化二亚苯基碘鎓 | 2-(1,3-二甲基-2,6-二氧代-2,3-二氢-1H-嘌呤-7(6H)-基)-N-(4-异丙基苯基)乙酰胺 | 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑 | HC-067047 | AMG9810 | GSK1016790A | SAR7334 | PF-4840154 | RN-1734 | AMG 517 | 3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺 | 冰素

ML204物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
404.4±33.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₁₈N₂

[ 分子量 ]:
226.317

[ 闪点 ]:
198.4±25.4 °C

[ 精确质量 ]:
226.147003

[ PSA ]:
16.13000

[ LogP ]:
3.92

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.617

[ 储存条件 ]:
-20℃

ML204安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危险品运输编码 ]:
NONH for all modes of transport

ML204合成路线

详细合成路线

ML204上下游产品

ML204上游产品

ML204下游产品

ML204文献

Do male secondary sexual characters correlate with testis size and sperm length in the small hairy maggot blowfly?

Zoology (Jena.) 118 , 439-45, (2015)

The phenotype-linked fertility hypothesis proposes that secondary sexual characters (SSCs) advertise a male's fertility to prospective mates. However, findings from empirical studies attempting to tes...

更多文献