<生产厂家价格>

乙酰氧肟酸

乙酰氧肟酸用途

Acetohydroxamic acid是一种有效的不可逆细菌和植物尿素酶抑制剂, 用于辅助治疗慢性尿路感染。

乙酰氧肟酸名称

[ CAS 号 ]:
546-88-3

[ 中文名 ]:
乙酰氧肟酸

[ 英文名 ]:
Acetohydroxamic acid

[中文别名 ]:

[英文别名 ]:

Acetamide, N-hydroxy-
Acetohydroxamic acid
methanecarbohydroxamic acid
EINECS 208-913-8
N-Hydroxyacetamide
N-acetylhydroxylamine
Acetomenadione
acethydroxamic acid
methylenehydroxamic acid
Acetylhydroxylamine

乙酰氧肟酸生物活性

[ 描述 ]:

Acetohydroxamic acid是一种有效的不可逆细菌和植物尿素酶抑制剂, 用于辅助治疗慢性尿路感染。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Sharma M, et al. Biotransformation of Acetamide to Acetohydroxamic Acid at Bench Scale Using Acyl Transferase Activity of Amidase of Geobacillus pallidus BTP-5x MTCC 9225. Indian J Microbiol. 2012 Mar;52(1):76-82.

[相关活性小分子]

乙酰氧肟酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
231.4ºC at 760 mmHg

[ 熔点 ]:
88-90 °C(lit.)

[ 分子式 ]:
C₂H₅NO₂

[ 分子量 ]:
75.067

[ 精确质量 ]:
75.032028

[ PSA ]:
49.33000

[ LogP ]:
-1.59

[ 外观性状 ]:
白色结晶固体

[ 折射率 ]:
1.421

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Moisture and Temperature Sensitive

乙酰氧肟酸MSDS

详细MSDS(安全技术说明书)

乙酰氧肟酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AK8157000

CHEMICAL NAME :: Acetohydroxamic acid

CAS REGISTRY NUMBER :: 546-88-3

LAST UPDATED :: 199410

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C2-H5-N-O2

MOLECULAR WEIGHT :: 75.08

WISWESSER LINE NOTATION :: QMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 750 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 20 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 152,225,1985

乙酰氧肟酸安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H360

[ 警示性声明 ]:
P201-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R61

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
3263

[ WGK德国 ]:
3

[ RTECS号 ]:
AK8157000

[ 包装等级 ]:
II

[ 海关编码 ]:
2942000000

乙酰氧肟酸上下游产品

乙酰氧肟酸上游产品

乙酰氧肟酸下游产品

乙酰氧肟酸海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

乙酰氧肟酸文献

CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation.

Proc. Natl. Acad. Sci. U. S. A. 112 , 5875-82, (2015)

Mitosis is commonly thought to be associated with reduced cap-dependent protein translation. Here we show an alternative control mechanism for maintaining cap-dependent translation during mitosis reve...

BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1.

J. Neurosci. 35(3) , 972-84, (2015)

Although the MAP kinase-interacting kinases (MNKs) have been known for >15 years, their roles in the regulation of protein synthesis have remained obscure. Here, we explore the involvement of the MNKs...

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

更多文献