间二氯苯

间二氯苯用途

用于有机合成。间二氯苯与氯乙酰氯经Friedel-Crafts反应，得2,4,ω-三氯苯乙酮，用作广谱抗真菌药物咪康唑的中间体。在存在氯化铁或铝汞的条件下进行氯化反应，主要生成1,2,4-三氯苯。存在催化剂的条件下，于550-850℃水解生成间氯苯酚和间苯二酚。以氧化铜为催化剂，在加压下150-200℃与浓氨水反应生成间苯二胺。
是医药、农药、染料等工业的重要中间体
邻二氯苯是一种重要的有机化工原料，在农药上既是杀虫剂三氯杀虫酯的原料，用于合成其中间体1-(3，4-二氯苯基)-2，2，2-三氯乙醇，也可合成另一个重要的农药中间体邻苯二胺，此外，它还作为溶剂用于染料、医药、树脂、橡胶等作业，或作为除锈剂、脱脂剂等
用于染料制造，也用作有机合成中间体和溶剂
广泛用于染料、医药、农药等行业的中间体
间二氯苯是重要的有机合成原料，是杀菌剂抑霉唑、丙环唑、乙环唑的原料，也是杀虫剂杀虫畏的原料。

间二氯苯名称

[ CAS 号 ]:
541-73-1

[ 中文名 ]:
1,3-二氯苯

[ 英文名 ]:
1,3-Dichlorobenzene

[中文别名 ]:

间二氯苯

[英文别名 ]:

iazine
Benzene, 1,3-dichloro-
meta-dichlorobenzene
m-dichlorobenzene
2,4-dichloro-benzene
1,4-Dichlorobenzene
pyrimidine acid
Miazine
Pyrimidin
1,3-DIAZINE

间二氯苯物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
180.4±0.0 °C at 760 mmHg

[ 熔点 ]:
-24 °C

[ 分子式 ]:
C₆H₄Cl₂

[ 分子量 ]:
147.002

[ 闪点 ]:
63.3±0.0 °C

[ 精确质量 ]:
145.969009

[ LogP ]:
3.42

[ 外观性状 ]:
无色至淡黄色液体带有芳香气味

[ 蒸汽压 ]:
1.2±0.3 mmHg at 25°C

[ 折射率 ]:
1.549

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

[ 稳定性 ]:
Stability Combustible. Incompatible with strong oxidizing agents, aluminium, aluminium alloys. Moisture-sensitive.

[ 水溶解性 ]:
0.0123 g/100 mL (25 ºC)

[ 凝固点 ]:
-24℃

间二氯苯MSDS

详细MSDS(安全技术说明书)

间二氯苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ4499000

CHEMICAL NAME :: Benzene, m-dichloro-

CAS REGISTRY NUMBER :: 541-73-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C6-H4-Cl2

MOLECULAR WEIGHT :: 147.00

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1062 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1470 mg/kg/10D-I

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - changes in calcium Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3330 mg/kg/90D-I

TOXIC EFFECTS :: Endocrine - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 175 mg/kg/24H

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 2,111,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2135 No. of Facilities: 49 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 418 (estimated) No. of Female Employees: 80 (estimated)

间二氯苯安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H411

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R22;R51/53

[ 安全声明 (欧洲) ]:
S61-S45-S36/37-S16-S7

[ 危险品运输编码 ]:
UN 3082 9/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
CZ4499000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
29036990

间二氯苯合成路线

详细合成路线

间二氯苯上下游产品

间二氯苯上游产品

间二氯苯下游产品

间二氯苯制备

其制备方法有以下几种。
以氯苯为原料进一步氯化，得到对二氯苯、邻二氯苯还有间二氯苯。一般分离的方法采用混合二氯苯进行连续蒸馏，塔顶馏出对位和间位二氯苯，冷冻结晶析出对二氯苯，母液再进行精馏而得到间二氯苯，塔釜是粗邻二氯苯，再在闪蒸塔进行闪蒸馏出邻二氯苯。目前混合二氯苯采用吸附分离的方法，采用分子筛为吸附剂，以气相混合二氯苯进入吸附塔，可选择性吸附对二氯苯，吸余液为间位和邻位二氯苯，经精馏分别得到间二氯苯和邻二氯苯。吸附温度180～200℃，吸附压力为常压。
1.间苯二胺重氮法：间苯二胺在亚硝酸钠和硫酸存在下进行重氮化，重氮化温度在0～5℃，重氮液在氯化亚铜存在下水解生成间二氯苯。

2.间氯苯胺法：采用间氯苯胺为原料，在亚硝酸钠和盐酸存在下进行重氮化，重氮液在氯化亚铜存在下水解生成间二氯苯。

以上几种制备方法中，最适用于工业化并成本较低的方法是混二氯苯的吸附分离法。国内已有生产装置进行生产。

间二氯苯海关

[ 海关编码 ]: 2903911000

[ 中文概述 ]:
2903911000 邻二氯苯。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:5.5%。普通关税:30.0%

[ Summary ]:
2903911000 1,3-dichlorobenzene。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%

间二氯苯文献

QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.

Eur. J. Med. Chem. 43 , 714-40, (2008)

Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...

[Cloning and quantitative expression of chlorocatechol 1,2-dioxygenase gene].

Huan Jing Ke Xue 30(2) , 606-9, (2009)

The chlorocatechol 1,2-dioxygenase gene, designated as tcbC (J5-2) (GenBank Accession No. EF111021), was cloned from total DNA of Pseudomonas aeruginosa J5-2 which can degrade 1,2,4-trichlorobenzene. ...

Optimizations of packed sorbent and inlet temperature for large volume-direct aqueous injection-gas chromatography to determine high boiling volatile organic compounds in water.

J. Chromatogr. A. 1356 , 221-9, (2014)

For the expanded application area, fast trace analysis of certain high boiling point (i.e., 150-250 °C) volatile organic compounds (HVOCs) in water, a large volume-direct aqueous injection-gas chromat...

更多文献