1,2,4-三氯苯

1,2,4-三氯苯用途

【用途一】
用作制造农药、变压器油、润滑油等的溶剂，染料载体，绝缘和冷却流体的添加剂，也是制造2,5-二氯苯酚的原料
【用途二】
1，2，4-三氯苯是合成杀螨剂三氯杀螨砜和除草剂麦草畏的中间体，还可用作医药、染料的原料，以及制备四氯苯和多氯酚的原料，也是用途很广的高沸点溶剂和变压器内电阻液的原料。
【用途三】
医药、染料、农药的原料，也是用途很广的高沸点溶剂，变压器内电阻液的原料。
【用途四】
溶剂。有机合成。杀虫剂。染料中间体。高纯1,2，4-三氯苯也可满足变压器油、导热油等多方面的化工和电力工业产品生产的要求。
【用途五】
溶剂。有机合成。杀虫剂。染料中间体。医药；染料；农药的原料，也是用途很广的高沸点溶剂，变压器内电阻液的原料。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他

1,2,4-三氯苯名称

[ CAS 号 ]:
120-82-1

[ 中文名 ]:
三氯苯

[ 英文名 ]:
1,2,4-Trichlorobenzene

[中文别名 ]:

1,2,4-三氯苯

[英文别名 ]:

1,2,5-Trichlorobenzene
EINECS 204-428-0
1,4,5-trichlorobenzene
1,2,4-Trichlorbenzene
Benzene, 1,2,4-trichloro-
MFCD00000547
1,2,4-trichloro-benzene
Trojchlorobenzen
1,2,4-Trichlorobenzene
Hostetex l-pec

1,2,4-三氯苯物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
211.4±20.0 °C at 760 mmHg

[ 熔点 ]:
16 °C(lit.)

[ 分子式 ]:
C₆H₃Cl₃

[ 分子量 ]:
181.447

[ 闪点 ]:
126.7±0.0 °C

[ 精确质量 ]:
179.930038

[ LogP ]:
3.82

[ 外观性状 ]:
无色液体带有一种令人愉快的气味

[ 蒸汽密度 ]:
>6 (vs air)

[ 蒸汽压 ]:
0.3±0.4 mmHg at 25°C

[ 折射率 ]:
1.567

[ 储存条件 ]:
库房通风低温干燥,与食品添加剂分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Combustible.

[ 水溶解性 ]:
INSOLUBLE

1,2,4-三氯苯MSDS

详细MSDS(安全技术说明书)

1,2,4-三氯苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC2100000

CHEMICAL NAME :: Benzene, 1,2,4-trichloro-

CAS REGISTRY NUMBER :: 120-82-1

BEILSTEIN REFERENCE NO. :: 0956819

LAST UPDATED :: 199712

DATA ITEMS CITED :: 31

MOLECULAR FORMULA :: C6-H3-Cl3

MOLECULAR WEIGHT :: 181.44

WISWESSER LINE NOTATION :: GR BG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 756 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6139 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1223 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 280 mg/kg/14D-C

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7380 mg/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1800 mg/kg

SEX/DURATION :: female 9-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 750 mg/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 2,111,1987 *** REVIEWS *** ACGIH TLV-CL 37 mg/m3 (5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-BELGIUM:STEL 5 ppm (37 mg/m3) JAN 1993 OEL-DENMARK:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-FINLAND:TWA 5 ppm (40 mg/m3);STEL 10 ppm (74 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-GERMANY:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (40 mg/m3);STEL 5 ppm (40 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,2,4-TRICHLOROBENZENE-air:CL 5 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83334 No. of Facilities: 74 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 1687 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83334 No. of Facilities: 78 (estimated) No. of Industries: 6 No. of Occupations: 14 No. of Employees: 4033 (estimated) No. of Female Employees: 1463 (estimated)

1,2,4-三氯苯安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H410

[ 警示性声明 ]:
P273-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R38;R50/53

[ 安全声明 (欧洲) ]:
S23-S37/39-S60-S61-S45-S36/37-S16

[ 危险品运输编码 ]:
UN 2321 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
DC2100000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29036990

1,2,4-三氯苯合成路线

详细合成路线

1,2,4-三氯苯上下游产品

1,2,4-三氯苯上游产品

1,2,4-三氯苯下游产品

1,2,4-三氯苯制备

1.热解法干燥的六六六无毒体在热解釜中加热热即得三氯苯，同时副产大量氯化氢。

2.碱解法六六六无毒体与石灰乳共热即得三氯苯，同时副产大量氯化钙液。

上述二法所得三氯苯均为1,2,4-三氯苯；1,3,5-三氯苯；1,2,3-三氯苯三种异构体的混合物，以1,2,4-三氯苯为主要组分。石灰乳法生产的三氯苯中，1,2,4-三氯苯含量在75%以上，1,2,3-三氯苯约占20%。

1,2,4-三氯苯海关

[ 海关编码 ]: 2903999090

[ 中文概述 ]:
2903999090 其他芳烃卤化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

1,2,4-三氯苯文献

QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.

Eur. J. Med. Chem. 43 , 714-40, (2008)

Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...

Understanding Solidification of Polythiophene Thin Films during Spin-Coating: Effects of Spin-Coating Time and Processing Additives.

Sci. Rep. 5 , 13288, (2015)

Spin-coating has been used extensively in the fabrication of electronic devices; however, the effects of the processing parameters have not been fully explored. Here, we systematically characterize th...

Development of a partition-controlled dosing system for cell assays.

Chem. Res. Toxicol. 23(11) , 1806-14, (2010)

Hydrophobic and volatile chemicals have proven to be difficult to dose in cell assays. Cosolvents are often needed to dissolve these chemicals in cell culture medium. Moreover, the free concentration ...

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