20Α-羟基胆固醇

20Α-羟基胆固醇用途

20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) 是平滑 (smo) 癌蛋白的变构激活剂,在以 NIH3T3 细胞的基因转录报告实验中,激活 hedgehog (Hh) 信号通路的 EC50 值为 3 μM。

20Α-羟基胆固醇名称

[ CAS 号 ]:
516-72-3

[ 中文名 ]:
20Alpha-羟基胆固醇

[ 英文名 ]:
20(S)-Hydroxycholesterol

[中文别名 ]:

[英文别名 ]:

20α-Hydroxy Cholesterol
20ALPHA-HYDROXYCHOLESTEROL

20Α-羟基胆固醇生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 干细胞及 Wnt 通路 >> SMO

研究领域 >> 癌症

[ 靶点 ]

EC50: 3 μM (hedgehog signaling pathway)[1]

[参考文献]

[1]. Nachtergaele S, et al. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol. 2012 Jan 8;8(2):211-20.

[2]. Nedelcu D, et al, Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat Chem Biol. 2013 Sep;9(9):557-64.

20Α-羟基胆固醇物理化学性质

[ 密度 ]:
1.03g/cm3

[ 沸点 ]:
512.3ºC at 760mmHg

[ 熔点 ]:
136-137ºC

[ 分子式 ]:
C₂₇H₄₆O₂

[ 分子量 ]:
402.65

[ 闪点 ]:
213.1ºC

[ 精确质量 ]:
402.35000

[ PSA ]:
40.46000

[ LogP ]:
6.50360

[ 折射率 ]:
1.538

[ 储存条件 ]:
-20°C Freezer

20Α-羟基胆固醇MSDS

20Α-羟基胆固醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

20Α-羟基胆固醇合成路线

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20Α-羟基胆固醇文献

In vitro osteoinductive effects of hydroxycholesterol on human adipose-derived stem cells are mediated through the hedgehog signaling pathway.

Plast. Reconstr. Surg. 134(5) , 960-8, (2014)

Human adipose-derived stem cells have been identified as a potential source of cells for use in bone tissue engineering because of their ready availability, ease of harvest, and susceptibility to oste...

Conversion of exogenous cholesterol into glycoalkaloids in potato shoots, using two methods for sterol solubilisation.

PLoS ONE 8 , e82955, (2013)

Steroidal glycoalkaloids (SGA) are toxic secondary metabolites naturally occurring in the potato, as well as in certain other Solanaceous plant species, such as tomato, eggplant and pepper. To investi...

Oxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipids.

PLoS ONE 5 , e10181, (2010)

Many gram-positive bacteria produce pore-forming exotoxins that contain a highly conserved, 12-residue domain (ECTGLAWEWWRT) that binds cholesterol. This domain is usually flanked N-terminally by argi...

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