5-乙酰氨基水杨酸

5-乙酰氨基水杨酸用途

N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) 是 5-Aminosalicylic Acid (HY-15027) 的代谢物,具有内窥镜活性。N-Acetyl mesalazine 可用于溃疡性结肠炎的研究。

5-乙酰氨基水杨酸名称

[ CAS 号 ]:
51-59-2

[ 中文名 ]:
5-乙酰氨基水杨酸

[ 英文名 ]:
N-Acetyl Mesalazine

[中文别名 ]:

氮位N-乙酰基美沙拉嗪

[英文别名 ]:

CJ 46A
N-Acetyl Mesalazine
5-Acetamidosalicylic acid
N-Acetyl-5-aminosalicylic acid
3-Carboxyparacetamol
5-acetylamino salicylic acid
5-acetamido-2-hydroxy-benzoic acid

5-乙酰氨基水杨酸生物活性

[ 描述 ]:

N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) 是 5-Aminosalicylic Acid (HY-15027) 的代谢物,具有内窥镜活性。N-Acetyl mesalazine 可用于溃疡性结肠炎的研究。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Allgayer H, et al. Modulation of base hydroxylation by bile acids and salicylates in a model of human colonic mucosal DNA: putative implications in colonic cancer. Dig Dis Sci. 1999 Apr;44(4):761-7.

[2]. Fukuda T, et al. Mucosal concentrations of N-acetyl-5-aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine. J Gastroenterol Hepatol. 2020 Nov;35(11):1878-1885.

5-乙酰氨基水杨酸物理化学性质

[ 密度 ]:
1.462 g/cm3

[ 沸点 ]:
480.2ºC at 760 mmHg

[ 熔点 ]:
228-230ºC

[ 分子式 ]:
C₉H₉NO₄

[ 分子量 ]:
195.17

[ 闪点 ]:
244.2ºC

[ 精确质量 ]:
195.05300

[ PSA ]:
86.63000

[ LogP ]:
1.12180

[ 外观性状 ]:
淡棕色晶体

[ 折射率 ]:
1.661

[ 储存条件 ]:
2-8°C

5-乙酰氨基水杨酸MSDS

5-乙酰氨基水杨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2924299090

5-乙酰氨基水杨酸合成路线

5-乙酰氨基水杨酸上下游产品

5-乙酰氨基水杨酸上游产品

5-乙酰氨基水杨酸下游产品

5-乙酰氨基水杨酸海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

5-乙酰氨基水杨酸文献

Simultaneous determination of 5-aminosalicylic acid, acetyl-5-aminosalicylic acid and 2,5-dihydroxybenzoic acid in endoscopic intestinal biopsy samples in humans by high-performance liquid chromatography with electrochemical detection.

J. Pharm. Biomed. Anal. 14(1-2) , 175-80, (1995)

A high-performance liquid chromatographic method for the simultaneous determination of 5-aminosalicylic acid (5-ASA), acetyl-5-aminosalicylic acid (Ac-5-ASA) and 2,5-dihydroxybenzoic acid (5-HSA) in h...

Safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild-to-moderate active ulcerative colitis: results of a randomized, double-blind study.

J. Pediatr. Gastroenterol. Nutr. 49(5) , 571-9, (2009)

: A multicenter, double-blind study was conducted to evaluate the safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild-to-moderate ulcerative colitis (UC).: Sixty-eigh...

Radical-derived oxidation products of 5-aminosalicylic acid and N-acetyl-5-aminosalicylic acid.

J. Chromatogr. B, Biomed. Appl. 661(1) , 57-68, (1994)

5-Aminosalicylic acid is an agent effective in the treatment of chronic inflammatory bowel diseases. Its ability to scavenge radicals is considered to be a major factor responsible for its therapeutic...

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