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柠檬油素

柠檬油素用途

Citropten (5,7-Dimethoxycoumarin) 是从佛手柑油中分离出的一种香豆素。Citropten (5,7-Dimethoxycoumarin) 对 A2058 人黑色素瘤细胞株具有抗增殖活性。

柠檬油素名称

[ CAS 号 ]:
487-06-9

[ 中文名 ]:
5,7-二甲氧基香豆素

[ 英文名 ]:
Citropten

[中文别名 ]:

[英文别名 ]:

5,7-Dimethoxy-2H-1-benzopyran-2-one
MFCD00006870
5,7-dimethoxy-coumarin
EINECS 207-646-4
Limettin
Citropten
5,7-Dimethoxy-2H-chromen-2-one
2H-1-Benzopyran-2-one, 5,7-dimethoxy-
5,7-dimethoxychromen-2-one
5,7-Dimethoxycoumarin

柠檬油素生物活性

[ 描述 ]:

Citropten (5,7-Dimethoxycoumarin) 是从佛手柑油中分离出的一种香豆素。Citropten (5,7-Dimethoxycoumarin) 对 A2058 人黑色素瘤细胞株具有抗增殖活性。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Makki S, et al. High-performance liquid chromatographic determination of citropten and bergapten in suction blister fluid after solar product application in humans. J Chromatogr. 1991 Feb 15;563(2):407-13.

[2]. Wolny D, et al. Antiproliferative effect of valproic acid and 5,7-dimethoxycoumarin against A2058 human melanoma cells. Acta Pol Pharm. 2014 Nov-Dec;71(6):1056-9.

柠檬油素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
388.1±42.0 °C at 760 mmHg

[ 熔点 ]:
146-149 °C(lit.)

[ 分子式 ]:
C₁₁H₁₀O₄

[ 分子量 ]:
206.195

[ 闪点 ]:
176.3±27.9 °C

[ 精确质量 ]:
206.057907

[ PSA ]:
48.67000

[ LogP ]:
2.06

[ 外观性状 ]:
黄色至黄褐色的或棕色粉末或结晶粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.557

[ 储存条件 ]:
2-8°C

柠檬油素MSDS

详细MSDS(安全技术说明书)

柠檬油素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN6530000

CHEMICAL NAME :: Coumarin, 5,7-dimethoxy-

CAS REGISTRY NUMBER :: 487-06-9

BEILSTEIN REFERENCE NO. :: 0187066

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H10-O4

MOLECULAR WEIGHT :: 206.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 100 umol/L

REFERENCE :: PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 42,333,1981

柠檬油素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
43

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
GN6530000

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柠檬油素文献

Simultaneous determination of 16 phenolic constituents in Spatholobi Caulis by high performance liquid chromatography/electrospray ionization triple quadrupole mass spectrometry.

J. Pharm. Biomed. Anal. 102 , 110-8, (2014)

Spatholobi Caulis, the vine stem of Spatholobus suberectus Dunn, has been widely used in traditional Chinese and folk medicines for treatment of irregular menstruation, blood deficiency and rheumatalg...

Fatal kavalactone intoxication by suicidal intravenous injection.

Forensic Sci. Int. 249 , e7-11, (2015)

Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxioly...

Relative photomutagenicity of furocoumarins and limettin in the hypoxanthine phosphoribosyl transferase assay in V79 cells.

Chem. Res. Toxicol. 22(9) , 1639-47, (2009)

Furocoumarins are phototoxic and photomutagenic natural plant constituents found in many medicinal plants and food items. Because plants contain mixtures of several furocoumarins, there is a need for ...

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