丙炔酸

丙炔酸用途

【用途一】
用作有机合成中间体，可与甲醇在硫酸催化下生成丙炔酸甲酯，是生产抗病毒药物碘苷的原料
【用途二】
用于有机合成。可用于制取丙酸、均苯三甲酸、卤代丙烯酸、二卤代丙烯酸、二乙炔二羧酸、丙炔酸乙酯、吡唑啉酮、二溴巴豆酸，乙氧基巴豆酸等。丙炔酸与硫酸、甲醇加热回流可制得丙炔酸甲酯（C4H4O2，[922-67-8]），是抗病毒药物碘苷的原料。

丙炔酸名称

[ CAS 号 ]:
471-25-0

[ 中文名 ]:
丙炔酸

[ 英文名 ]:
Propiolic acidd

[中文别名 ]:

[英文别名 ]:

prop-2-ynoic acid
propargylic acid
Propynoic acid
2-propynoic acid
Propiolic acid
MFCD00004360
Acetylenecarboxylic acid
Propiolic Acidd
EINECS 207-437-8

丙炔酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
139.7±0.0 °C at 760 mmHg

[ 熔点 ]:
16-18 °C(lit.)

[ 分子式 ]:
C₃H₂O₂

[ 分子量 ]:
70.047

[ 闪点 ]:
58.9±0.0 °C

[ 精确质量 ]:
70.005478

[ PSA ]:
37.30000

[ LogP ]:
0.31

[ 外观性状 ]:
黏的黄色液体

[ 蒸汽压 ]:
3.7±0.5 mmHg at 25°C

[ 折射率 ]:
1.456

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、碱分开存放

[ 稳定性 ]:
Stable. Incompatible with bases, oxidizing agents, reducing agents. Combustible.

[ 水溶解性 ]:
miscible

丙炔酸MSDS

详细MSDS(安全技术说明书)

丙炔酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UD9300000

CHEMICAL NAME :: Propiolic acid

CAS REGISTRY NUMBER :: 471-25-0

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C3-H2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4953,1982

丙炔酸安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H301-H310-H314

[ 警示性声明 ]:
P280-P302 + P350-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R25;R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S24/25

[ 危险品运输编码 ]:
UN 2920 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
UD9300000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
29161980

丙炔酸上下游产品

丙炔酸上游产品

丙炔酸下游产品

丙炔酸制备

1.由丙炔醇氧化而得。将丙炔醇加入丙酮中搅拌，于20℃滴加铬酐的硫酸溶液，加毕，室温搅拌14h，即生成丙炔酸。

2.以乙炔钠和CO2在3.55-7.09MPa和90℃以下温度反应，即得。

丙炔酸海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

丙炔酸文献

Identification of the toxic trigger in mushroom poisoning.

Nat. Chem. Biol. 5 , 465-7, (2009)

We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans. This compound is responsible for fatal rhabdomyolysis, a...

Hierarchically functionalized magnetic core/multishell particles and their postsynthetic conversion to polymer capsules.

ACS Nano 9 , 4219-26, (2015)

The controlled synthesis of hierarchically functionalized core/multishell particles is highly desirable for applications in medicine, catalysis, and separation. Here, we describe the synthesis of hier...

Development of a tailor-made bis(oxazolidine)pyridine-metal catalyst for the [3+2] cycloaddition of azomethine imines with propiolates.

Chem. Commun. (Camb.) 49(71) , 7776-8, (2013)

A series of bis(oxazolidine)pyridine ligands (the PyBodines) were newly designed and synthesized for the development of a highly efficient, tailor-made catalyst for the [3+2] cycloaddition of azomethi...

更多文献

丙炔酸