1,4-二乙酰氧基-2-甲基萘

1,4-二乙酰氧基-2-甲基萘用途

甲萘二醇(二氢维生素K3)是甲萘醌类似物,是软骨下颗粒中反向氧化磷酸化的电子供体[1]。

1,4-二乙酰氧基-2-甲基萘名称

[ CAS 号 ]:
481-85-6

[ 中文名 ]:
1,4-二羟基-2-甲基萘

[ 英文名 ]:
Menadiol

[中文别名 ]:

[英文别名 ]:

Methylnaphthohydroquinone
2-methylnaphthalene-1,4-diol
Reduced vitamin K3
Menadiol
EINECS 207-573-8
2-methyl-1,4-naphthalenediol
Dihydrovitamin K3
2-Methyl-1,4-naphthalindiol
Vitamin K3H2
Reduced menadione

1,4-二乙酰氧基-2-甲基萘生物活性

[ 描述 ]:

甲萘二醇(二氢维生素K3)是甲萘醌类似物,是软骨下颗粒中反向氧化磷酸化的电子供体[1]。

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. Zhao Z, et al. Effects of site-directed mutations on heme reduction in Escherichia coli nitrate reductase A by menaquinol: a stopped-flow study. Biochemistry. 2003;42(48):14225-14233.

[2]. Taggart WV, et al. Menadiol as an electron donor for reversed oxidative phosphorylation in submitochondrial particles. Biochim Biophys Acta. 1972;267(3):439-443.

1,4-二乙酰氧基-2-甲基萘物理化学性质

[ 密度 ]:
1.274g/cm3

[ 沸点 ]:
391.6ºC at 760mmHg

[ 熔点 ]:
181℃

[ 分子式 ]:
C₁₁H₁₀O₂

[ 分子量 ]:
174.19600

[ 闪点 ]:
199.5ºC

[ 精确质量 ]:
174.06800

[ PSA ]:
40.46000

[ LogP ]:
2.55940

[ 外观性状 ]:
白色至黄色固体

[ 蒸汽压 ]:
1.08E-06mmHg at 25°C

[ 折射率 ]:
1.697

[ 储存条件 ]:
室温，干燥

1,4-二乙酰氧基-2-甲基萘毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ5075000

CHEMICAL NAME :: 1,4-Naphthalenediol, 2-methyl-

CAS REGISTRY NUMBER :: 481-85-6

BEILSTEIN REFERENCE NO. :: 1638194

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H10-O2

MOLECULAR WEIGHT :: 174.21

WISWESSER LINE NOTATION :: L66J BQ C1 EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 75,111,1942

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 143,585,1949

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,210,1941

1,4-二乙酰氧基-2-甲基萘安全信息

[ 危害码 (欧洲) ]:
C

1,4-二乙酰氧基-2-甲基萘合成路线

详细合成路线

1,4-二乙酰氧基-2-甲基萘上下游产品

1,4-二乙酰氧基-2-甲基萘上游产品

1,4-二乙酰氧基-2-甲基萘下游产品

1,4-二乙酰氧基-2-甲基萘制备

以2-甲基苯醌与丁二烯环合制得。加2-甲基苯醌和冰醋酸于反应釜中，搅拌溶解，通丁二烯，温度不超过
20℃，约5～6小时，在15～20℃密闭反应20小时，逐渐升温到60℃，赶尽丁二烯，在110～120℃回流３小时，制得本品。
　反应式为：