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卡硝唑

卡硝唑用途

Carnidazole 是一种硝基咪唑类的抗原虫剂 (antiprotozoal)。可用于滴虫感染的研究。

卡硝唑名称

[ CAS 号 ]:
42116-76-7

[ 中文名 ]:
卡硝唑

[ 英文名 ]:
Carnidazole

[英文别名 ]:

ME 108
Spartrix
Carnidazole
EINECS 255-663-0
UNII-RH5KI819JG

卡硝唑生物活性

[ 描述 ]:

Carnidazole 是一种硝基咪唑类的抗原虫剂 (antiprotozoal)。可用于滴虫感染的研究。

[ 相关类别 ]:

研究领域 >> 感染

[ 靶点 ]

Antiprotozoal[1]

[参考文献]

[1]. A Notowicz, et al. First Experiences With Single-Dose Treatment of Vaginal Trichomoniasis With Carnidazole (R 25831). Br J Vener Dis. 1977 Apr;53(2):129-31.

卡硝唑物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
422.8±51.0 °C at 760 mmHg

[ 分子式 ]:
C₈H₁₂N₄O₃S

[ 分子量 ]:
244.271

[ 闪点 ]:
209.5±30.4 °C

[ 精确质量 ]:
244.063004

[ PSA ]:
116.99000

[ LogP ]:
0.72

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.627

[ 储存条件 ]:
-20°C

卡硝唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FD3912000

CHEMICAL NAME :: Carbamothioic acid, (2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-, O-methyl ester

CAS REGISTRY NUMBER :: 42116-76-7

BEILSTEIN REFERENCE NO. :: 0620260

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H12-N4-O3-S

MOLECULAR WEIGHT :: 244.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 213 umol/L

REFERENCE :: TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 3,51,1983

卡硝唑安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
C

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
FD3912000

[ 海关编码 ]:
2933290090

卡硝唑海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

卡硝唑文献

Determination of the antitubercular drug PA-824 in rat plasma, lung and brain tissues by liquid chromatography tandem mass spectrometry: application to a pharmacokinetic study.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 988 , 187-94, (2015)

A selective, sensitive and high performance liquid chromatography-tandem mass spectrometry (LC-(ESI)MS/MS) method has been developed and validated for the quantification of the potent antitubercular d...

In vitro nitroimidazole resistance of Trichomonas gallinae and successful therapy with an increased dosage of ronidazole in racing pigeons (Columba livia domestica).

J. Vet. Pharmacol. Ther. 15(4) , 409-15, (1992)

Six out of eight different Trichomonas gallinae strains isolated from racing pigeons proved to be resistant to the nitroimidazole drugs ronidazole, carnidazole and metronidazole. The minimal cytocidal...

Structural characterization of drugs and oxygenated metabolites by laser microprobe mass spectrometry (LAMMA).

Biomed. Environ. Mass Spectrom. 16(1-12) , 121-9, (1988)

Laser microprobe mass analysis (LAMMA) was used for the structural characterization of polyfunctional drugs and their oxygenated metabolites, in particular the N-oxides. The spectra usually yield the ...

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卡硝唑