奥硝唑
奥硝唑用途
奥硝唑名称
[ CAS 号 ]:
16773-42-5
[ 中文名 ]:
奥硝唑
[ 英文名 ]:
Ornidazole
[中文别名 ]:
[英文别名 ]:
- UNII:62XCK0G93T
- Ornidazole
- MFCD00057960
- EINECS 240-826-0
奥硝唑生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
奥硝唑物理化学性质
[ 密度 ]:
1.5±0.1 g/cm3
[ 沸点 ]:
443.2±40.0 °C at 760 mmHg
[ 熔点 ]:
85-90°C
[ 分子式 ]:
C7H10ClN3O3
[ 分子量 ]:
219.626
[ 闪点 ]:
221.9±27.3 °C
[ 精确质量 ]:
219.041061
[ PSA ]:
83.87000
[ LogP ]:
0.69
[ 外观性状 ]:
结晶固体
[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C
[ 折射率 ]:
1.617
[ 储存条件 ]:
-20°C Freezer
奥硝唑MSDS
奥硝唑毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NI5460000
- CHEMICAL NAME :
- Imidazole-1-ethanol, alpha-(chloromethyl)-2-methyl-5-nitro-
- CAS REGISTRY NUMBER :
- 16773-42-5
- BEILSTEIN REFERENCE NO. :
- 0614299
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C7-H10-Cl-N3-O3
- MOLECULAR WEIGHT :
- 219.65
- WISWESSER LINE NOTATION :
- T5N CNJ A1YQ1G B1 ENW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1780 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1139 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 375 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 36400 mg/kg/13W-C
- TOXIC EFFECTS :
- Related to Chronic Data - changes in prostate weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 6500 mg/kg/26D-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 292 gm/kg/2Y-C
- TOXIC EFFECTS :
- Brain and Coverings - changes in brain weight Blood - changes in erythrocyte (RBC) count Related to Chronic Data - changes in testicular weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 25600 mg/kg
- SEX/DURATION :
- male 64 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 35 gm/kg
- SEX/DURATION :
- male 61 day(s) pre-mating female 14 day(s) pre-mating - 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 11200 mg/kg
- SEX/DURATION :
- male 4 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 5600 mg/kg
- SEX/DURATION :
- male 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
MUTATION DATA
- TYPE OF TEST :
- Host-mediated assay
- TEST SYSTEM :
- Rodent - mouse Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 50 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 86,243,1981
奥硝唑安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302
[ 危害码 (欧洲) ]:
Xn: Harmful;
[ 风险声明 (欧洲) ]:
R22
[ 安全声明 (欧洲) ]:
S36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
NI5460000
[ 海关编码 ]:
2933290090
奥硝唑上下游产品
奥硝唑上游产品
奥硝唑下游产品
奥硝唑海关
[ 海关编码 ]: 2933290090
[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
奥硝唑文献
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 960 , 105-15, (2014)
An UHPLC-MS/MS method was developed for the quantitative confirmatory analysis of residues of nitroimidazole drugs (dimetridazole, ipronidazole, metronidazole, ornidazole and ronidazole) and their cor...
Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance.Front. Microbiol. 6 , 354, (2015)
Antimicrobial chemotherapy is critical in the fight against infectious diseases caused by Entamoeba histolytica. Among the drugs available for the treatment of amebiasis, metronidazole (MTZ) is consid...
Genetically different clonal isolates of Trichomonas gallinae, obtained from the same bird, can vary in their drug susceptibility, an in vitro evidence.Parasitol. Int. 60(2) , 213-5, (2011)
Trichomonas gallinae is a flagellated protozoon which parasitizes in the upper digestive tract of different birds, especially columbiformes (doves and pigeons) and falconiformes. The parasite is also ...
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价格:
¥88.0/5g
¥268.0/25g
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产品详情:奥硝唑
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联系人:赖经理
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产品详情:[Perfemiker]奥硝唑,98%
公司名:上海阿拉丁生化科技股份有限公司
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¥132.9/100g
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联系人:阿拉丁李高志
产品详情:奥硝唑
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相关化合物
【奥硝唑】化源网提供奥硝唑CAS号16773-42-5,奥硝唑MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询奥硝唑上化源网,专业又轻松。>>电脑版:奥硝唑
标题:奥硝唑_MSDS_用途_密度_奥硝唑CAS号【16773-42-5】_化源网 地址:https://www.chemsrc.com/amp/cas/16773-42-5_325162.html