哌丙呋罗

哌丙呋罗用途

Piprofurol 是一种钙通道 (calcium channel) 抑制剂。Piprofurol 以浓度依赖的方式抑制大鼠主动脉离体钾去极化制剂中钙诱导的收缩,并使狗冠状动脉和兔基底动脉的 K+EC50值为 5 μM。

哌丙呋罗名称

[ CAS 号 ]:
40680-87-3

[ 中文名 ]:
哌丙呋罗

[ 英文名 ]:
Piprofurol

[英文别名 ]:

EINECS 255-035-6
Piprofurol
Piprofurol [INN]
Piprofurolum
Piprofurolum [INN-Latin]

哌丙呋罗生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 心血管疾病

[ 靶点 ]

5 μM(guinea-pig papillary muscle)[1]

[参考文献]

[1]. Pourrias B, et al. Calcium blocking properties of piprofurol. Arch Int Pharmacodyn Ther. 1985;274(2):223-239.

哌丙呋罗物理化学性质

[ 密度 ]:
1.214g/cm3

[ 沸点 ]:
640.7ºC at 760 mmHg

[ 分子式 ]:
C₂₆H₃₃NO₆

[ 分子量 ]:
455.54300

[ 闪点 ]:
341.3ºC

[ 精确质量 ]:
455.23100

[ PSA ]:
84.53000

[ LogP ]:
4.62440

[ 折射率 ]:
1.596

哌丙呋罗毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF6845120

CHEMICAL NAME :: 5-Benzofuranmethanol, 4,7-dimethoxy-alpha-(2-(4-hydroxyphenyl)ethyl)-6- (2-(1-piperidinyl)ethoxy)-

CAS REGISTRY NUMBER :: 40680-87-3

BEILSTEIN REFERENCE NO. :: 1276232

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C26-H33-N-O6

MOLECULAR WEIGHT :: 455.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 8,125,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,85,1974