阿魏酸乙酯

阿魏酸乙酯用途

Ethyl ferulate 是从大茴香分离得到的阿魏酸的天然亲酯衍生物,可诱导血红素氧合酶 1 (HO-1),保护大鼠神经元免受氧化应激。Ethyl ferulate也能够保护神经元免受 β 淀粉样肽(1-42)导致的全身性的氧化应激和神经毒性。

阿魏酸乙酯名称

[ CAS 号 ]:
4046-02-0

[ 中文名 ]:
阿魏酸乙酯

[ 英文名 ]:
Ethyl ferulate

[中文别名 ]:

[英文别名 ]:

MFCD00009190
4-Hydroxy-3-methoxycinnamic Acid Ethyl Ester
Ferulic acid ethyl ester
Ethyl 4-Hydroxy-3-MethoxycinnaMate
EINECS 223-745-5
Ethyl Ferulate
Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate

阿魏酸乙酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Scapagnini G, et al. Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid Redox Signal. 2004 Oct;6(5):811-8.

[2]. Sultana R, et al. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochem. 2005 Feb;92(4):749-58.

阿魏酸乙酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
382.3±0.0 °C at 760 mmHg

[ 熔点 ]:
63-65 °C(lit.)

[ 分子式 ]:
C₁₂H₁₄O₄

[ 分子量 ]:
222.24

[ 闪点 ]:
132.5±17.2 °C

[ 精确质量 ]:
222.089203

[ PSA ]:
55.76000

[ LogP ]:
1.94

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.566

[ 储存条件 ]:
避免光

[ 水溶解性 ]:
可溶于：甲醇

阿魏酸乙酯MSDS

阿魏酸乙酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918990090

阿魏酸乙酯合成路线

阿魏酸乙酯上下游产品

阿魏酸乙酯上游产品

阿魏酸乙酯下游产品

阿魏酸乙酯海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

阿魏酸乙酯文献

Soluble and cell wall-bound phenolic acids and ferulic acid dehydrodimers in rye flour and five bread model systems: insight into mechanisms of improved availability.

J. Sci. Food Agric. 95(5) , 1103-15, (2015)

The bread-making process influences bread components, including phenolics that significantly contribute to its antioxidant properties. Five bread model systems made from different rye cultivars were i...

Hydroxycinnamic acid ethyl esters as precursors to ethylphenols in wine.

J. Agric. Food Chem. 60(9) , 2293-8, (2012)

A method for determining ethyl coumarate and ethyl ferulate in wine using GC-MS with deuterium-labeled analogues has been developed and used to measure the evolution of these two esters during the pro...

Inhibitory effects of caffeic acid ethyl ester on H2O2-induced cytotoxicity and DNA single-strand breaks in Chinese hamster V79 cells.

Biosci. Biotechnol. Biochem. 60(2) , 316-8, (1996)

Cytotoxicity and DNA single-strand breaks caused by H2O2 were assessed by a colony formation assay and a DNA precipitation assay, respectively, with Chinese hamster V79 cells. In both assays, caffeic ...

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