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2-氟乙醇

2-氟乙醇用途

【用途一】
用作医药、农药中间体
【用途二】
抗菌药物氟罗沙星（fleroxacin）的中间体。2-氟乙醇及其衍生物用于毒杀啮齿动物，其衍生物可作除草剂及毒杀一些植物害虫。

2-氟乙醇名称

[ CAS 号 ]:
371-62-0

[ 中文名 ]:
2-氟乙醇

[ 英文名 ]:
2-Fluoroethanol

[中文别名 ]:

[英文别名 ]:

2-Fluoroethan-1-ol
2-fluoro-ethano
MFCD00002828
EINECS 206-740-2
Ethanol, 2-fluoro-
2-fluoroethyl alcohol
2-fluroethanol
FLUOROETHANOL
Glycolfluorohydrin
2-Fluoroethanol

2-氟乙醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
103.5±0.0 °C at 760 mmHg

[ 熔点 ]:
−26.5 °C(lit.)

[ 分子式 ]:
C₂H₅FO

[ 分子量 ]:
64.059

[ 闪点 ]:
31.1±0.0 °C

[ 精确质量 ]:
64.032440

[ PSA ]:
20.23000

[ LogP ]:
-0.47

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
17.8±0.3 mmHg at 25°C

[ 折射率 ]:
1.326

[ 储存条件 ]:
室温

2-氟乙醇MSDS

2-氟乙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KL1575000

CHEMICAL NAME :: Ethanol, 2-fluoro-

CAS REGISTRY NUMBER :: 371-62-0

BEILSTEIN REFERENCE NO. :: 1730857

LAST UPDATED :: 199701

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C2-H5-F-O

MOLECULAR WEIGHT :: 64.07

WISWESSER LINE NOTATION :: Q2F

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,515,1986

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/m3/10M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1750 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 20,465,1968

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/m3/10M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JCSOA9 Journal of the Chemical Society. (London, UK) 1926-65. For publisher information, see JCPRB4. Volume(issue)/page/year: -,773,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOCEAH Journal of Organic Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1936- Volume(issue)/page/year: 21,739,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 172,1139,1953

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 7 mg/m3/10M

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 1500 mg/m3/10M

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 35 mg/m3/10M

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 25 mg/m3/10M

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JCSOA9 Journal of the Chemical Society. (London, UK) 1926-65. For publisher information, see JCPRB4. Volume(issue)/page/year: -,1279,1949

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 150 mg/m3/10M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB158-508 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 48,225,1951

2-氟乙醇安全信息

[ 符号 ]:

GHS02, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H300 + H310 + H330

[ 警示性声明 ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T: Toxic;T+: Very toxic;F: Flammable;

[ 风险声明 (欧洲) ]:
R10;R26/27/28

[ 安全声明 (欧洲) ]:
S36/37/39-S45

[ 危险品运输编码 ]:
UN 3383 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
KL1575000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2905590090

2-氟乙醇合成路线

2-氟乙醇上下游产品

2-氟乙醇上游产品

2-氟乙醇下游产品

2-氟乙醇制备

将2-氯乙醇96.6g（1.2mol）滴加到94ml乙二醇和105g（1.8mol）无水氟化钾的混合物中，在180℃保温反应2h，得2-氟乙醇32.34g，收率42.1%。

2-氟乙醇海关

[ 海关编码 ]: 2905590090

[ 中文概述 ]:
2905590090 其他无环醇的卤化、磺化等衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

2-氟乙醇文献

Hydrolytic pathway of 5-fluorouracil in aqueous solutions for clinical use.

J. Pharm. Biomed. Anal. 98 , 446-62, (2014)

The purpose of the study was to investigate the degradation pathway of 5-fluorouracil (FU) in the situation of commercial formulations for clinical use, namely FU dissolved in sodium hydroxide (NaOH) ...

Measuring the relative hydrogen-bonding strengths of alcohols in aprotic organic solvents.

ChemPhysChem 16(1) , 160-8, (2015)

Voltammetric experiments with 9,10-anthraquinone and 1,4-benzoquinone performed under controlled moisture conditions indicate that the hydrogen-bond strengths of alcohols in aprotic organic solvents c...

2-Halogeno-ethanols as an uncoupler of phosphorylation in rat liver mitochondria.

Experientia 36(5) , 537-9, (1980)

2-Chloroethanol, 2-bromoethanol and 2,2,2-trifluoroethanol at a concentration of 0.79 vol.% stimulated state 4 respiration and released oligomycin inhibition of state 3 respiration. 2-Fluoroethanol an...

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