N-甲基酪胺

N-甲基酪胺用途

N-Methyltyramine 是一种原生物碱,可以从多种植物中分离出来。N-Mmethyltyramine 是一种 α2-肾上腺素受体拮抗剂。N-Methyltyramine 通过刺激胃泌素和胰腺分泌来增强食欲和食物消化。N-甲基酪胺可松弛小鼠小肠平滑肌并抑制小肠蠕动。

N-甲基酪胺名称

[ CAS 号 ]:
370-98-9

[ 中文名 ]:
N-甲基酪胺

[ 英文名 ]:
N-Methyltyramine

[中文别名 ]:

4-[2-(甲基氨基)乙基]苯酚

[英文别名 ]:

N-Methyltyramine
4-Hydroxy-N-methylphenethylamine
Methyl-4-tyramine
Phenol, p-[2-(methylamino)ethyl]-
Phenol, 4-[2-(methylamino)ethyl]-
4-[2-(Methylamino)ethyl]phenol
N-methyl-p-Tyramine
WIN 5582
Tyramine,N-methyl
tyramine, N-methyl-

N-甲基酪胺生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 代谢疾病

[参考文献]

[1]. Stohs SJ, et al. A review of the receptor binding and pharmacological effects of N-methyltyramine. Phytother Res. 2015 Jan;29(1):14-6.

[2]. Ni J, et al. Effect of N-methyltyramine on the regulation of adrenergic receptors via enzymatic epinephrine synthesis for the treatment of gastrointestinal disorders. Biomed Pharmacother. 2019 Mar;111:1393-1398.

N-甲基酪胺物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
270.9±15.0 °C at 760 mmHg

[ 熔点 ]:
121 - 126°C(lit.)

[ 分子式 ]:
C₉H₁₃NO

[ 分子量 ]:
151.21

[ 闪点 ]:
119.7±11.0 °C

[ 精确质量 ]:
151.099716

[ PSA ]:
32.26000

[ LogP ]:
0.86

[ 外观性状 ]:
浅米色至深米色固体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.541

[ 储存条件 ]:
2-8°C

N-甲基酪胺MSDS

N-甲基酪胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL8300000

CHEMICAL NAME :: Phenol, p-(2-methylaminoethyl)-

CAS REGISTRY NUMBER :: 370-98-9

BEILSTEIN REFERENCE NO. :: 2357129

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H13-N-O

MOLECULAR WEIGHT :: 151.23

WISWESSER LINE NOTATION :: QR D2M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,341,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,341,1952

N-甲基酪胺安全信息

[ 危害码 (欧洲) ]:
C

[ 海关编码 ]:
2922299090

N-甲基酪胺合成路线

N-甲基酪胺上下游产品

N-甲基酪胺上游产品

N-甲基酪胺下游产品

N-甲基酪胺海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%