Dehydroleucodine

Dehydroleucodine用途

Dehydroleucodine 是一种从 Gynoxys verrucosa 分离的倍半萜内酯。 Dehydroleucodine 是肥大细胞稳定剂,可抑制化合物 48/80 诱导的肥大细胞脱粒。Dehydroleucodine 可促进细胞凋亡 (apoptosis),并具有抑制胃溃疡和抗白血病作用。

Dehydroleucodine名称

[ CAS 号 ]:
36150-07-9

[ 中文名 ]:
(3aS,9aS,9bS)-6,9-二甲基-3-亚甲基-4,5,9a,9b-四氢-3aH-薁并[5,4-d]呋喃-2,7-二酮

[ 英文名 ]:
Dehydroleucodine

[英文别名 ]:

DEHYDROACHILLIN

Dehydroleucodine生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 炎症/免疫

[参考文献]

[1]. Paola E Ordóñez, et al. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. J Nat Prod. 2016 Apr 22;79(4):691-6.

[2]. Mariano E Vera, et al. Activation of human leukemic mast cell line LAD2 is modulated by dehydroleucodine and xanthatin. Leuk Lymphoma. 2012 Sep;53(9):1795-803.

[3]. Valeria V Costantino, et al. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. Cancer Lett. 2016 Mar 1;372(1):10-23.

Dehydroleucodine物理化学性质

[ 密度 ]:
1.2g/cm3

[ 沸点 ]:
450.6ºC at 760mmHg

[ 分子式 ]:
C₁₅H₁₆O₃

[ 分子量 ]:
244.28600

[ 闪点 ]:
203.1ºC

[ 精确质量 ]:
244.11000

[ PSA ]:
43.37000

[ LogP ]:
2.33970

[ 外观性状 ]:
粉末

[ 折射率 ]:
1.562

[ 储存条件 ]:
室温，避光

Dehydroleucodine安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

Dehydroleucodine文献

Antidiarrheal activity of dehydroleucodine isolated from Artemisia douglasiana.

Fitoterapia 79(1) , 1-5, (2008)

Dehydroleucodine (DhL), a sesquiterpene lactone obtained from Artemisia douglasiana, was screened for antidiarrheal effects. DhL inhibited castor oil-induced diarrhea in mice by judged by a decrease i...

Role of mast cells in gastrointestinal mucosal defense.

Biocell 27(2) , 163-72, (2003)

The purpose of this review, based on studies from our laboratory as well as from others, is to summarize salient features of mast cell immunobiology and to describe their associations with gastrointes...

Effect of dehydroleucodine on intestinal transit: structural basis of the interaction with the α(2)-adrenergic receptor.

Eur. Biophys. J. 40(8) , 981-6, (2011)

The activity of dehydroleucodine, a sesquiterpene lactone obtained from Artemisia douglasiana, was studied in mice small intestinal transit. Its mechanism was evaluated in the presence of several adre...

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