Dehydroleucodine

更新时间：2024-04-02 23:36:43

Dehydroleucodine结构式	常用名	Dehydroleucodine	英文名	Dehydroleucodine
	CAS号	36150-07-9	分子量	244.28600
	密度	1.2g/cm3	沸点	450.6ºC at 760mmHg
	分子式	C₁₅H₁₆O₃	熔点	N/A
	MSDS	中文版美版	闪点	203.1ºC

Dehydroleucodine用途

Dehydroleucodine 是一种从 Gynoxys verrucosa 分离的倍半萜内酯。 Dehydroleucodine 是肥大细胞稳定剂,可抑制化合物 48/80 诱导的肥大细胞脱粒。Dehydroleucodine 可促进细胞凋亡 (apoptosis),并具有抑制胃溃疡和抗白血病作用。

中文名	(3aS,9aS,9bS)-6,9-二甲基-3-亚甲基-4,5,9a,9b-四氢-3aH-薁并[5,4-d]呋喃-2,7-二酮
英文名	Dehydroleucodine
英文别名	更多

描述	Dehydroleucodine 是一种从 Gynoxys verrucosa 分离的倍半萜内酯。 Dehydroleucodine 是肥大细胞稳定剂,可抑制化合物 48/80 诱导的肥大细胞脱粒。Dehydroleucodine 可促进细胞凋亡 (apoptosis),并具有抑制胃溃疡和抗白血病作用。
相关类别	信号通路 >> 细胞凋亡 >> 细胞凋亡研究领域 >> 癌症研究领域 >> 炎症/免疫
参考文献	[1]. Paola E Ordóñez, et al. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. J Nat Prod. 2016 Apr 22;79(4):691-6. [2]. Mariano E Vera, et al. Activation of human leukemic mast cell line LAD2 is modulated by dehydroleucodine and xanthatin. Leuk Lymphoma. 2012 Sep;53(9):1795-803. [3]. Valeria V Costantino, et al. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. Cancer Lett. 2016 Mar 1;372(1):10-23.

描述

相关类别

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 炎症/免疫

参考文献

[1]. Paola E Ordóñez, et al. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. J Nat Prod. 2016 Apr 22;79(4):691-6.

[2]. Mariano E Vera, et al. Activation of human leukemic mast cell line LAD2 is modulated by dehydroleucodine and xanthatin. Leuk Lymphoma. 2012 Sep;53(9):1795-803.

[3]. Valeria V Costantino, et al. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. Cancer Lett. 2016 Mar 1;372(1):10-23.

密度	1.2g/cm3
沸点	450.6ºC at 760mmHg
分子式	C₁₅H₁₆O₃
分子量	244.28600
闪点	203.1ºC
精确质量	244.11000
PSA	43.37000
LogP	2.33970
外观性状	粉末
折射率	1.562
储存条件	室温，避光

危险品运输编码	NONH for all modes of transport

Antidiarrheal activity of dehydroleucodine isolated from Artemisia douglasiana.

Fitoterapia 79(1) , 1-5, (2008)

Dehydroleucodine (DhL), a sesquiterpene lactone obtained from Artemisia douglasiana, was screened for antidiarrheal effects. DhL inhibited castor oil-induced diarrhea in mice by judged by a decrease i...

Role of mast cells in gastrointestinal mucosal defense.

Biocell 27(2) , 163-72, (2003)

The purpose of this review, based on studies from our laboratory as well as from others, is to summarize salient features of mast cell immunobiology and to describe their associations with gastrointes...

Effect of dehydroleucodine on intestinal transit: structural basis of the interaction with the α(2)-adrenergic receptor.

Eur. Biophys. J. 40(8) , 981-6, (2011)

The activity of dehydroleucodine, a sesquiterpene lactone obtained from Artemisia douglasiana, was studied in mice small intestinal transit. Its mechanism was evaluated in the presence of several adre...

DEHYDROACHILLIN

11,13-Dehydroleucodin Dehydroleucodin Leucodin Lidbeckialactone Mesatlantin E