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Dianemycin

Dianemycin用途

Dianemycin (Nanchangmycin free base) 由 Streptomyces nanchangensis NS3226 产生的,抑制革兰氏阳性菌。Dianemycin 也是一种抗 Zika 病毒的广谱抗病毒药物。

Dianemycin名称

[ CAS 号 ]:
35865-33-9

[ 中文名 ]:
Dianemycin

[ 英文名 ]:
Dianemycin

[英文别名 ]:

Dianemycin

Dianemycin生物活性

[ 描述 ]:

Dianemycin (Nanchangmycin free base) 由 Streptomyces nanchangensis NS3226 产生的,抑制革兰氏阳性菌。Dianemycin 也是一种抗 Zika 病毒的广谱抗病毒药物。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

Bacteria[1] Zika virus[2]

[体外研究]

Dianemycin(南昌霉素)可用作家禽的生长促进剂和治疗鸡的球虫病。 Dianemycin具有抗药性疟疾菌株的活性[1]。 Dianemycin(Nanchangmycin)作为寨卡病毒(ZIKV)进入所有细胞类型的有效抑制剂,包括生理相关的原代细胞。 Dianemycin有效地减少了所有三种细胞类型中所有三种ZIKV毒株的感染。感染的IC50在0.1和0.4μM之间,而Dianemycin在这些范围内具有低毒性。此外,DENV被细胞类型的Dianemycin抑制[2]。

[参考文献]

[1]. Liu T, et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic Nanchangmycin. Chem Biol. 2008 May;15(5):449-58.

[2]. Rausch K, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815.

Dianemycin物理化学性质

[ 密度 ]:
1.21g/cm3

[ 沸点 ]:
910.3ºC at 760mmHg

[ 分子式 ]:
C₄₇H₇₈O₁₄

[ 分子量 ]:
867.11

[ 闪点 ]:
256.4ºC

[ 精确质量 ]:
866.53900

[ PSA ]:
188.90000

[ LogP ]:
6.14960

[ 折射率 ]:
1.549

[ 储存条件 ]:
-20°C，密闭，干燥

Dianemycin毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HL5521000

CHEMICAL NAME :: Dianemycin

CAS REGISTRY NUMBER :: 35865-33-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C47-H78-O14

MOLECULAR WEIGHT :: 867.25

WISWESSER LINE NOTATION :: T6OXTJ DQ E1 FY1&1UY1&VY1&1Y1&VQ B-& BT5OXTJ E1 E- ET6OXTJ C1 DO- FT6OTJ B1 CO1& B-& BT5OXTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 3,47,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 3,47,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 22,161,1969