35865-33-9

• 常用中文名：Dianemycin
• 常用英文名：Dianemycin
• CAS号：35865-33-9
• 分子式：C₄₇H₇₈O₁₄
• 分子量：867.11
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2017-07-19 15:10:45
• 更新时间：2024-01-29 22:34:55
• Dianemycin (Nanchangmycin free base) 由 Streptomyces nanchangensis NS3226 产生的,抑制革兰氏阳性菌。Dianemycin 也是一种抗 Zika 病毒的广谱抗病毒药物。

名称

• 中文名: Dianemycin
• 英文名: (E)-8-[7-hydroxy-2-[2-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-9-(5-methoxy-6-methyloxan-2-yl)oxy-4,10-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl]-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-2,4,6-trimethyl-5-oxonon-6-enoic acid
• 英文别名: Dianemycin

物化性质

• 密度: 1.21g/cm3
• 沸点: 910.3ºC at 760mmHg
• 分子式: C₄₇H₇₈O₁₄
• 分子量: 867.11
• 闪点: 256.4ºC
• 精确质量: 866.53900
• PSA: 188.90000
• LogP: 6.14960
• 折射率: 1.549
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Dianemycin (Nanchangmycin free base) 由 Streptomyces nanchangensis NS3226 产生的,抑制革兰氏阳性菌。Dianemycin 也是一种抗 Zika 病毒的广谱抗病毒药物。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点:

  Bacteria[1] Zika virus[2]

• 体外研究: Dianemycin(南昌霉素)可用作家禽的生长促进剂和治疗鸡的球虫病。 Dianemycin具有抗药性疟疾菌株的活性[1]。 Dianemycin(Nanchangmycin)作为寨卡病毒(ZIKV)进入所有细胞类型的有效抑制剂,包括生理相关的原代细胞。 Dianemycin有效地减少了所有三种细胞类型中所有三种ZIKV毒株的感染。感染的IC50在0.1和0.4μM之间,而Dianemycin在这些范围内具有低毒性。此外,DENV被细胞类型的Dianemycin抑制[2]。
• 参考文献:

  [1]. Liu T, et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic Nanchangmycin. Chem Biol. 2008 May;15(5):449-58.

  [2]. Rausch K, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HL5521000 CHEMICAL NAME : Dianemycin CAS REGISTRY NUMBER : 35865-33-9 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C47-H78-O14 MOLECULAR WEIGHT : 867.25 WISWESSER LINE NOTATION : T6OXTJ DQ E1 FY1&1UY1&VY1&1Y1&VQ B-& BT5OXTJ E1 E- ET6OXTJ C1 DO- FT6OTJ B1 CO1& B-& BT5OXTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 3,47,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 3,47,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 22,161,1969