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β-Estradiol-6-one 6-(O-carboxymethyloxime)

用途

β-Estradiol-6-one 6-(O-carboxymethyloxime) 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

名称

[ CAS 号 ]:
35048-47-6

[ 英文名 ]:
β-Estradiol-6-one 6-(O-carboxymethyloxime)

[英文别名 ]:

Beta-Estradiol-6-one 6-(O-carboxymethyloxime)
17β-estradiol 6-O-(carboxymethyl)oxime
17beta-estradiol 6-O-(carboxymethyl)oxime
β-Estradiol-6-one 6-(O-carboxymethyloxime)
SS-ESTRADIOL-6-ONE 6-(O-CARBOXYMETHYLOXIME)

生物活性

[ 描述 ]:

β-Estradiol-6-one 6-(O-carboxymethyloxime) 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl-Chain

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
572.6±60.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₂₅NO₅

[ 分子量 ]:
359.416

[ 闪点 ]:
300.1±32.9 °C

[ 精确质量 ]:
359.173279

[ PSA ]:
99.35000

[ LogP ]:
2.31

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.680

[ 储存条件 ]:
2-8°C，密封，干燥

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

合成路线

详细合成路线

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文献

A convenient homogeneous enzyme immunoassay for estradiol detection.

Biotechnol. Appl. Biochem. 58(1) , 75-82, (2011)

A convenient homogeneous enzyme immunoassay for estradiol is described. Unlike heterogeneous immunoassays, which require time-consuming separation steps or expensive automated systems, homogeneous imm...

Histochemical estrogen receptor assay.

Am. J. Clin. Pathol. 76(3) , 365, (1981)

Estrogen receptors in human breast cancer. II. Correlation between the histochemical method and biochemical assay.

Virchows Arch.,. B, Cell Pathol. 40(1) , 27-37, (1982)

The present study defines criteria for determining the presence of estrogen-receptors in human breast carcinomas demonstrated by a histochemical assay using 17 beta-estradiol-carboxy-methyl-oxim-bovin...

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