还原氟哌啶醇

还原氟哌啶醇用途

Reduced haloperidol is an active metabolite of haloperidol formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake.

还原氟哌啶醇名称

[ CAS 号 ]:
34104-67-1

[ 中文名 ]:
还原氟哌啶醇

[ 英文名 ]:
Haloperidol Metabolite II

[英文别名 ]:

Haloperidol metabolite II

还原氟哌啶醇物理化学性质

[ 密度 ]:
1.247g/cm3

[ 沸点 ]:
531.2ºC at 760 mmHg

[ 熔点 ]:
125-127°C

[ 分子式 ]:
C₂₁H₂₅ClFNO₂

[ 分子量 ]:
377.88000

[ 闪点 ]:
275.1ºC

[ 精确质量 ]:
377.15600

[ PSA ]:
43.70000

[ LogP ]:
4.21420

[ 外观性状 ]:
white

[ 折射率 ]:
1.589

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
DMSO: soluble10mg/mL

还原氟哌啶醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933399090

还原氟哌啶醇合成路线

详细合成路线

还原氟哌啶醇上下游产品

还原氟哌啶醇上游产品

还原氟哌啶醇下游产品

还原氟哌啶醇海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

还原氟哌啶醇文献

Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.

Psychopharmacology 205 , 21-33, (2009)

We evaluated the effects of haloperidol and its metabolites on capsaicin-induced mechanical hypersensitivity (allodynia) and on nociceptive pain induced by punctate mechanical stimuli in mice.Subcutan...

Determination of haloperidol and reduced haloperidol in human serum by liquid chromatography after fluorescence labeling based on the Suzuki coupling reaction.

Anal. Bioanal. Chem 386(3) , 719-24, (2006)

A simultaneous method for the determination of haloperidol (HP) and its metabolite, reduced haloperidol (RHP), in human serum was developed by means of high-performance liquid chromatography (HPLC) wi...

Plasma reduced haloperidol/haloperidol ratios in schizophrenic patients treated with high dosages of haloperidol.

Eur. Neuropsychopharmacol. 4(2) , 119-26, (1994)

Plasma haloperidol (HL) and reduced haloperidol (RH) levels were measured in 60 schizophrenic patients treated with high to very high HL doses of 40-200 mg/day. Plasma samples were obtained at steady-...

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