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乙拉西坦

乙拉西坦用途

Etiracetam (UCB 6474) 是乙酰胆碱的激动剂，是一种抗精神病药物。活性低于它的S型对映异构体 Levetiracetam (UCB L059)。

乙拉西坦名称

[ CAS 号 ]:
33996-58-6

[ 中文名 ]:
益智酰胺

[ 英文名 ]:
Etiracetam

[中文别名 ]:

乙拉西坦

[英文别名 ]:

1-Pyrrolidineacetamide, α-ethyl-2-oxo-
UCB 6474
(±)-a-Ethyl-2-oxo-1-pyrrolidineacetamide
ucb L059
T5NVTJ AY2&VZ
Etiracetam
2-(2-Oxo-1-pyrrolidinyl)butanamide
α-Ethyl-2-oxo-1-pyrrolidineacetamide
UNII:230447L0GL
Levetiracetam Racemic Mixture

乙拉西坦生物活性

[ 描述 ]:

Etiracetam (UCB 6474) 是乙酰胆碱的激动剂,是一种抗精神病药物。活性低于它的S型对映异构体 Levetiracetam (UCB L059)。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 神经疾病

[ 靶点 ]

Acetylcholine[1].

[参考文献]

[1]. Hovinga CA, et al. Levetiracetam: a novel antiepileptic drug. Pharmacotherapy. 2001 Nov;21(11):1375-88.

乙拉西坦物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
395.9±25.0 °C at 760 mmHg

[ 分子式 ]:
C₈H₁₄N₂O₂

[ 分子量 ]:
170.209

[ 闪点 ]:
193.2±23.2 °C

[ 精确质量 ]:
170.105530

[ PSA ]:
64.39000

[ LogP ]:
-0.67

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.519

[ 储存条件 ]:
2-8℃

乙拉西坦安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319-H411

[ 警示性声明 ]:
P273-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

乙拉西坦文献

Inhibition of excitatory synaptic transmission in hippocampal neurons by levetiracetam involves Zn²⁺-dependent GABA type A receptor-mediated presynaptic modulation.

J. Pharmacol. Exp. Ther. 348(2) , 246-59, (2014)

Levetiracetam (LEV) is an antiepileptic drug with a unique but as yet not fully resolved mechanism of action. Therefore, by use of a simplified rat-isolated nerve-bouton preparation, we have investiga...

Efficacy and safety of pregabalin versus levetiracetam as adjunctive therapy in patients with partial seizures: a randomized, double-blind, noninferiority trial.

Epilepsia 55(7) , 1048-57, (2014)

To assess the comparative efficacy and safety of pregabalin and levetiracetam for the reduction of seizure frequency in patients with partial seizures.This was a randomized, double-blind, flexible-dos...

The established status epilepticus trial 2013.

Epilepsia 54 Suppl 6 , 89-92, (2013)

Benzodiazepine-refractory status epilepticus (established status epilepticus, ESE) is a relatively common emergency condition with several widely used treatments. There are no controlled, randomized, ...

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乙拉西坦

乙拉西坦用途

乙拉西坦名称

乙拉西坦生物活性

乙拉西坦物理化学性质

乙拉西坦安全信息

乙拉西坦文献

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