乙拉西坦

更新时间:2024-01-02 23:19:35

乙拉西坦结构式
乙拉西坦结构式
品牌特惠专场
常用名 乙拉西坦 英文名 Etiracetam
CAS号 33996-58-6 分子量 170.209
密度 1.2±0.1 g/cm3 沸点 395.9±25.0 °C at 760 mmHg
分子式 C8H14N2O2 熔点 N/A
MSDS N/A 闪点 193.2±23.2 °C
符号 GHS07 GHS09
GHS07, GHS09
信号词 Warning

 乙拉西坦用途


Etiracetam (UCB 6474) 是乙酰胆碱的激动剂,是一种抗精神病药物。活性低于它的S型对映异构体 Levetiracetam (UCB L059)。

 乙拉西坦名称

中文名 益智酰胺
英文名 2-(2-oxopyrrolidin-1-yl)butanamide
中文别名 乙拉西坦
英文别名 更多

 乙拉西坦生物活性

描述 Etiracetam (UCB 6474) 是乙酰胆碱的激动剂,是一种抗精神病药物。活性低于它的S型对映异构体 Levetiracetam (UCB L059)。
相关类别
靶点

Acetylcholine[1].

参考文献

[1]. Hovinga CA, et al. Levetiracetam: a novel antiepileptic drug. Pharmacotherapy. 2001 Nov;21(11):1375-88.

 乙拉西坦物理化学性质

密度 1.2±0.1 g/cm3
沸点 395.9±25.0 °C at 760 mmHg
分子式 C8H14N2O2
分子量 170.209
闪点 193.2±23.2 °C
精确质量 170.105530
PSA 64.39000
LogP -0.67
蒸汽压 0.0±0.9 mmHg at 25°C
折射率 1.519
储存条件 2-8℃

 乙拉西坦安全信息

符号 GHS07 GHS09
GHS07, GHS09
信号词 Warning
危害声明 H302-H319-H411
警示性声明 P273-P305 + P351 + P338
危害码 (欧洲) Xn:Harmful;
风险声明 (欧洲) R22;R36
安全声明 (欧洲) S26
危险品运输编码 UN 3077 9 / PGIII

 乙拉西坦文献27

更多文献
Inhibition of excitatory synaptic transmission in hippocampal neurons by levetiracetam involves Zn²⁺-dependent GABA type A receptor-mediated presynaptic modulation.

J. Pharmacol. Exp. Ther. 348(2) , 246-59, (2014)

Levetiracetam (LEV) is an antiepileptic drug with a unique but as yet not fully resolved mechanism of action. Therefore, by use of a simplified rat-isolated nerve-bouton preparation, we have investiga...

Efficacy and safety of pregabalin versus levetiracetam as adjunctive therapy in patients with partial seizures: a randomized, double-blind, noninferiority trial.

Epilepsia 55(7) , 1048-57, (2014)

To assess the comparative efficacy and safety of pregabalin and levetiracetam for the reduction of seizure frequency in patients with partial seizures.This was a randomized, double-blind, flexible-dos...

The established status epilepticus trial 2013.

Epilepsia 54 Suppl 6 , 89-92, (2013)

Benzodiazepine-refractory status epilepticus (established status epilepticus, ESE) is a relatively common emergency condition with several widely used treatments. There are no controlled, randomized, ...

 乙拉西坦英文别名

1-Pyrrolidineacetamide, α-ethyl-2-oxo-
UCB 6474
(±)-a-Ethyl-2-oxo-1-pyrrolidineacetamide
ucb L059
T5NVTJ AY2&VZ
Etiracetam
2-(2-Oxo-1-pyrrolidinyl)butanamide
α-Ethyl-2-oxo-1-pyrrolidineacetamide
UNII:230447L0GL
Levetiracetam Racemic Mixture
乙拉西坦
2-(2-Oxopyrrolidin-1-yl)butyramide
(±)-α-Ethyl-2-oxo-1-pyrrolidineacetamide
2-(2-oxopyrrolidin-1-yl)butanamide
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