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4-硝基儿茶酚

4-硝基儿茶酚用途

4-硝基邻苯二酚是一种有效的脂氧合酶抑制剂[1]。

4-硝基儿茶酚名称

[ CAS 号 ]:
3316-09-4

[ 中文名 ]:
4-硝基儿茶酚

[ 英文名 ]:
4-nitrocatechol

[中文别名 ]:

[英文别名 ]:

EINECS 222-009-0
1,2-Benzenediol, 4-nitro-
1,2-dihydroxy-4-nitrobenzene
[14C]-4-Nitrocatechol
NITROCATECHOL (MIX OF ISOMERS)
4-nitrocathecol
3,4-dihydroxynitrobenzene
4-Nitro-1,2-benzenediol
4-nitrocatechol
4-Nitrobenzol-1,2-diol

4-硝基儿茶酚生物活性

[ 描述 ]:

4-硝基邻苯二酚是一种有效的脂氧合酶抑制剂[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶

[ 靶点 ]

Human Endogenous Metabolite

Microbial Metabolite

[参考文献]

[1]. Ewa Skrzypczak-Jankun, et al. Soybean lipoxygenase-3 in complex with 4-nitrocatechol. Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):613-5.

4-硝基儿茶酚物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
358.2±32.0 °C at 760 mmHg

[ 熔点 ]:
173-177 °C(lit.)

[ 分子式 ]:
C₆H₅NO₄

[ 分子量 ]:
155.108

[ 闪点 ]:
168.8±13.6 °C

[ 精确质量 ]:
155.021851

[ PSA ]:
86.28000

[ LogP ]:
1.68

[ 外观性状 ]:
固体;Light yellow to Amber to Dark green powder to crystal

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.668

[ 储存条件 ]:
室温，密封，干燥

4-硝基儿茶酚MSDS

4-硝基儿茶酚安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2908999090

4-硝基儿茶酚合成路线

4-硝基儿茶酚上下游产品

4-硝基儿茶酚上游产品

4-硝基儿茶酚下游产品

4-硝基儿茶酚海关

[ 海关编码 ]: 2908999090

[ 中文概述 ]:
2908999090 其他酚及酚醇的卤化等衍生物（包括其磺化、硝化或亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

4-硝基儿茶酚文献

Effect of commercially available green and black tea beverages on drug-metabolizing enzymes and oxidative stress in Wistar rats.

Food Chem. Toxicol. 70 , 120-7, (2014)

The effect of commercially available green tea (GT) and black tea (BT) drinks on drug metabolizing enzymes (DME) and oxidative stress in rats was investigated. Male Wistar rats were fed a laboratory c...

Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols.

Org. Biomol. Chem. 13(13) , 3887-99, (2015)

The green tea polyphenol epigallocatechin-3-gallate (EGCG) was reported to effectively antagonize the ability of Bortezomib (BZM) to induce apoptosis in cancer cells. This interaction was attributed t...

Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.

Drug Metab. Dispos. 43(1) , 126-39, (2014)

Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept study investig...

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