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Reversan

Reversan用途

Reversan (CBLC4H10) 是一种高效无毒的多药耐药相关蛋白 1 (MRP1) 和 P-糖蛋白 (Pgp) 抑制剂。

Reversan名称

[ CAS 号 ]:
313397-13-6

[ 中文名 ]:
Reversan

[ 英文名 ]:
Reversan

[英文别名 ]:

Reversan
CBLC4H10
HMS2467O12

Reversan生物活性

[ 描述 ]:

Reversan (CBLC4H10) 是一种高效无毒的多药耐药相关蛋白 1 (MRP1) 和 P-糖蛋白 (Pgp) 抑制剂。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 跨膜转运 >> P-糖蛋白

[ 靶点 ]

Multidrug resistance-associated protein 1, P-glycoprotein[1]

[参考文献]

[1]. Tivnan A, et al. Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Front Neurosci. 2015 Jun 16;9:218.

[2]. Burkhart CA, et al. Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 2009 Aug 15;69(16):6573-80.

Reversan物理化学性质

[ 分子式 ]:
C₂₆H₂₇N₅O₂

[ 分子量 ]:
441.52

[ 精确质量 ]:
441.21600

[ PSA ]:
75.25000

[ LogP ]:
4.02810

[ 储存条件 ]:
2-8℃

ReversanMSDS

详细MSDS(安全技术说明书)

Reversan安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

Reversan文献

Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replication.

Hepatology 62 , 397-408, (2015)

Hepatitis A virus (HAV) and hepatitis C virus (HCV) are two positive-strand RNA viruses sharing a similar biology, but causing opposing infection outcomes, with HAV always being cleared and HCV establ...

Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments.

Mol. Cancer Ther. 14 , 952-63, (2015)

Antibody-drug conjugates (ADC) are emerging as clinically effective therapy. We hypothesized that cancers treated with ADCs would acquire resistance mechanisms unique to immunoconjugate therapy and th...

ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.

J. Natl. Cancer Inst. 103 , 1236-51, (2011)

Although the prognostic value of the ATP-binding cassette, subfamily C (ABCC) transporters in childhood neuroblastoma is usually attributed to their role in cytotoxic drug efflux, certain observations...

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