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酪氨酸磷酸化抑制剂A1

酪氨酸磷酸化抑制剂A1用途

Tyrphostin A1(AG9)能抑制巨噬细胞培养中CD40L刺激的IL-12产生和抗原诱导的Th1细胞生成。

酪氨酸磷酸化抑制剂A1名称

[ CAS 号 ]:
2826-26-8

[ 中文名 ]:
(4-甲氧基苄烯)丙二腈

[ 英文名 ]:
Tyrphostin A1

[中文别名 ]:

[英文别名 ]:

AG 9
(4-Methoxybenzylidene)malonitrile
Tyrphostin A1
Tyrphostin 1
2-(4-Methoxybenzylidene)malononitrile
(4-Methoxybenzylidene)malononitrile
2-[(4-methoxyphenyl)methylidene]malononitrile
2-[(4-methoxyphenyl)methylene]malononitrile
p-methoxybenzylidenemalononitrile
MFCD00019787

酪氨酸磷酸化抑制剂A1生物活性

[ 描述 ]:

Tyrphostin A1(AG9)能抑制巨噬细胞培养中CD40L刺激的IL-12产生和抗原诱导的Th1细胞生成。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 白细胞介素相关

研究领域 >> 炎症/免疫

[参考文献]

[1]. Du C, et al. Inhibition of CD40 signaling pathway by tyrphostin A1 reduces secretion of IL-12 in macrophage, Th1 cell development and experimental allergic encephalomyelitis in SJL/J mice. J Neuroimmunol. 2001 Mar 1;114(1-2):69-79.

[2]. Ogura T, et al. Activation of background membrane conductance by the tyrosine kinase inhibitor tyrphostin A23 and its inactive analog tyrphostin A1 in guinea pig ventricular myocytes. Jpn J Pharmacol. 2001 Nov;87(3):235-9.

[相关活性小分子]

酪氨酸磷酸化抑制剂A1物理化学性质

[ 密度 ]:
1.169g/cm3

[ 沸点 ]:
352.4ºC at 760mmHg

[ 熔点 ]:
113-116ºC(lit.)

[ 分子式 ]:
C₁₁H₈N₂O

[ 分子量 ]:
184.19400

[ 闪点 ]:
148.8ºC

[ 精确质量 ]:
184.06400

[ PSA ]:
56.81000

[ LogP ]:
2.12576

[ 外观性状 ]:
固体;Light orange to Yellow to Green powder to crystal

[ 蒸汽压 ]:
3.85E-05mmHg at 25°C

[ 折射率 ]:
1.589

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
chloroform: soluble50mg/mL, clear, light yellow

酪氨酸磷酸化抑制剂A1MSDS

酪氨酸磷酸化抑制剂A1安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
UN 3439 6.1/PG III

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 海关编码 ]:
2926909090

酪氨酸磷酸化抑制剂A1合成路线

酪氨酸磷酸化抑制剂A1上下游产品

酪氨酸磷酸化抑制剂A1上游产品

酪氨酸磷酸化抑制剂A1下游产品

酪氨酸磷酸化抑制剂A1海关

[ 海关编码 ]: 2926909090

[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

酪氨酸磷酸化抑制剂A1文献

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.

J. Med. Chem. 32 , 2344, (1989)

A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic series of molecules with a progressive increase in affinity toward the su...

Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors.

Science 242(4880) , 933-5, (1988)

A systematic series of low molecular weight protein tyrosine kinase inhibitors were synthesized; they had progressively increasing affinity over a 2500-fold range toward the substrate site of epiderma...

Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2.

Nat. Med. 5(1) , 71-7, (1999)

Adeno-associated virus 2 (AAV)-based vectors have gained attention as a potentially useful alternative to the more commonly used retroviral and adenoviral vectors for human gene therapy. Although AAV ...

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