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Fluphenazine enanthate

Fluphenazine enanthate用途

Fluphenazine enanthate 是第一种长效抗精神病药物,用于治疗精神分裂症。

Fluphenazine enanthate名称

[ CAS 号 ]:
2746-81-8

[ 中文名 ]:
氟奋乃静庚酸酯

[ 英文名 ]:
Fluphenazine enanthate

[英文别名 ]:

Fluphenazine enantate
Fluphenazinenanthat
Fluphenanzin-aenanthat
Fluphenazin-aenanthsaeureester
Moditen-retard
Prolixin Enanthate
fluphenazine enanthate
fluphenazine O-enantate
Eutimox
EINECS 220-385-0

Fluphenazine enanthate生物活性

[ 描述 ]:

Fluphenazine enanthate 是第一种长效抗精神病药物,用于治疗精神分裂症。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体内研究]

氟奋乃静对映体(2,4,8mg/kg；IM)对回避行为的抑制作用分别持续16、23和28天[1]。氟奋乃静(8mg/kg)的饮酒行为在给药后24小时内几乎完全被抑制[1]。氟奋乃嗪(8 mg/kg)在大鼠体内产生短暂的体重损失[1]。动物模型：Wistar品系雄性成年大鼠54只[1]剂量：2、4、8mg/kg给药：中指数(IM)结果：3种剂量的氟哌嗪分别在16、23、28d时对回避行为有明显抑制作用。

[参考文献]

[1]. Kuribara H, et al. Effects of fluphenazine enanthate and fluphenazine decanoate on discriminated avoidanceresponse and water drinking behavior in rats. Psychopharmacology (Berl). 1979 Sep;65(1):1-6.

[2]. Brissos S, et al. The role of long-acting injectable antipsychotics in schizophrenia: a critical appraisal. Ther Adv Psychopharmacol. 2014 Oct;4(5):198-219.

Fluphenazine enanthate物理化学性质

[ 密度 ]:
1.181g/cm3

[ 沸点 ]:
629.4ºC at 760mmHg

[ 分子式 ]:
C₂₉H₃₈F₃N₃O₂S

[ 分子量 ]:
549.69100

[ 闪点 ]:
334.4ºC

[ 精确质量 ]:
549.26400

[ PSA ]:
61.32000

[ LogP ]:
6.77020

[ 蒸汽压 ]:
9.41E-16mmHg at 25°C

[ 折射率 ]:
1.544

Fluphenazine enanthate毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MJ2450000

CHEMICAL NAME :: Heptanoic acid, 2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl )- 1-piperazinyl)ethyl ester

CAS REGISTRY NUMBER :: 2746-81-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C29-H38-F3-N3-O2-S

MOLECULAR WEIGHT :: 549.76

WISWESSER LINE NOTATION :: T C666 BN ISJ EXFFF B3- AT6N DNTJ D2OV6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 357 ug/kg

TOXIC EFFECTS :: Behavioral - muscle weakness

REFERENCE :: AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 119,779,1963

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Human

DOSE/DURATION :: 1633 ug/kg

TOXIC EFFECTS :: Musculoskeletal - other changes

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,1071,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,701,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,701,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03337

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,701,1982 *** REVIEWS *** TOXICOLOGY REVIEW ABPYBL Advances in Biochemical Psychopharmacology. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1969- Volume(issue)/page/year: 9,301,1974

Fluphenazine enanthate安全信息

[ 危险品运输编码 ]:
UN 3249

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

Fluphenazine enanthate文献

Ten year outcomes of outpatients with schizophrenia on conventional depot antipsychotics: a systematic chart review.

Int. Clin. Psychopharmacol. 28(5) , 261-6, (2013)

Long-term follow-up data of patients with schizophrenia on depot antipsychotics have been few and the longest follow-up period has been up to 7 years. We carried out a systematic chart review to exami...

Treatment of schizophrenia with depot preparations of fluphenazine, haloperidol, and risperidone among inpatients at state-operated psychiatric facilities.

Schizophr. Res. 119(1-3) , 153-9, (2010)

This study aimed to characterize the inpatient utilization of depot antipsychotics.The characteristics of adults with schizophrenia or schizoaffective disorder, hospitalized for at least 28 days, and ...

Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.

Acta Paediatr. Scand. 71(2) , 335-8, (1982)

A boy was born with a short sloping forehead, wide metopic suture, persistent metopic fontanelle, telecanthus, ocular hypertelorism, nystagmoid eye movements, bilateral cleft lip and palate, imperfora...

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