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六乙二醇

六乙二醇用途

Hexaethylene glycol 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

六乙二醇名称

[ CAS 号 ]:
2615-15-8

[ 中文名 ]:
六甘醇

[ 英文名 ]:
hexaethyleneglycol

[中文别名 ]:

[英文别名 ]:

EINECS 220-045-1
HEXAETHYLENE GLYCOL
Polyethylene glycol 300
MFCD00002877
3,6,9,12,15-Pentaoxaheptadecane-1,17-diol
hexa-PEG-diol
hexaethyleneglycol
PEG-6
Hexagol
Hexaoxyethylene glycol

六乙二醇生物活性

[ 描述 ]:

Hexaethylene glycol 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

PEGs

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

六乙二醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
378.3±0.0 °C at 760 mmHg

[ 熔点 ]:
5-7 °C(lit.)

[ 分子式 ]:
C₁₂H₂₆O₇

[ 分子量 ]:
282.331

[ 闪点 ]:
193.7±26.5 °C

[ 精确质量 ]:
282.167847

[ PSA ]:
86.61000

[ LogP ]:
-2.95

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.460

[ 储存条件 ]:
室温，密封

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

六乙二醇MSDS

六乙二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MM3670000

CHEMICAL NAME :: Hexaethylene glycol

CAS REGISTRY NUMBER :: 2615-15-8

BEILSTEIN REFERENCE NO. :: 1638281

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H26-O7

MOLECULAR WEIGHT :: 282.38

WISWESSER LINE NOTATION :: Q2/O2/ 5Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941

六乙二醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S23-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
MM3670000

[ 海关编码 ]:
2909499000

六乙二醇合成路线

六乙二醇上下游产品

六乙二醇上游产品

六乙二醇下游产品

六乙二醇海关

[ 海关编码 ]: 2909499000

[ 中文概述 ]:
2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

六乙二醇文献

Synthesis and evaluation of new spacers for use as dsDNA end-caps.

Bioconjug. Chem. 21(8) , 1545-53, (2010)

A series of aliphatic and aromatic spacer molecules designed to cap the ends of DNA duplexes have been synthesized. The spacers were converted into dimethoxytrityl-protected phosphoramidites as syntho...

Adsorption isotherms of aqueous C12E6 and cetyltrimethylammonium bromide surfactants on solid surfaces in the presence of low molecular weight coadsorbents.

Langmuir 25(10) , 5536-44, (2009)

In this work, we evaluate the effects of the low molecular weight compounds toluene, phenol, and 1-hexanol on the adsorption of two surfactants on one solid surface. The surfactants are cetyltrimethyl...

A nicked duplex decamer DNA with a PEG(6) tether.

Nucleic Acids Res. 29(5) , 1132-43, (2001)

A dumbbell double-stranded DNA decamer tethered with a hexaethylene glycol linker moiety (DDSDPEG), with a nick in the centre of one strand, has been synthesised. The standard NMR methods, E.COSY, TOC...

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