黄绿青霉素

黄绿青霉素用途

Citreoviridin 是一种来自 Penicillium citreoviride NRRL 2579 的毒素,抑制脑突触体 Na+/K+ ATPase,而在微粒体中,刺激 Na+/K+-ATPase 和 Mg2+-ATPase 活性。Citreoviridin 作用于人脐静脉内皮细胞,抑制细胞增殖并促进凋亡 (apoptosis)。

黄绿青霉素名称

[ CAS 号 ]:
25425-12-1

[ 中文名 ]:
黄绿青霉素

[ 英文名 ]:
(-)-Citreoviridin

[英文别名 ]:

Citreoviridin
CITREOVIRIDIN BIOCHEMICA
Citreoviridin A

黄绿青霉素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 心血管疾病

研究领域 >> 感染

[ 靶点 ]

Na+/K+-ATPase[1] Apoptosis[2]

[参考文献]

[1]. Datta SC, et al. Effect of citreoviridin, a mycotoxin from Penicillium citreoviride, on kinetic constants of acetylcholinesterase and ATPase in synaptosomes and microsomes from rat brain. Toxicon. 1981;19(4):555-62.

[2]. Hou H, et al. Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells. Environ Toxicol Pharmacol. 2014 Mar;37(2):828-36.

黄绿青霉素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
585.1±50.0 °C at 760 mmHg

[ 熔点 ]:
107-111℃

[ 分子式 ]:
C₂₃H₃₀O₆

[ 分子量 ]:
402.481

[ 闪点 ]:
197.7±23.6 °C

[ 精确质量 ]:
402.204254

[ PSA ]:
89.13000

[ LogP ]:
3.04

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±3.7 mmHg at 25°C

[ 折射率 ]:
1.569

[ 储存条件 ]:
2-8°C

黄绿青霉素安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H311-H315-H319-H331-H335-H361

[ 警示性声明 ]:
P261-P264-P280-P301 + P310-P305 + P351 + P338-P311

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
63-23/24/25-36/37/38

[ 安全声明 (欧洲) ]:
22-26-36/37/39-45

[ 危险品运输编码 ]:
UN 3172

[ RTECS号 ]:
UQ1235000

[ 包装等级 ]:
II

[ 海关编码 ]:
29322090

黄绿青霉素文献

Co-occurrence of aflatoxins B₁, B₂, G₁ and G₂, ochratoxin A, zearalenone, deoxynivalenol, and citreoviridin in rice in Brazil.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 29(4) , 694-703, (2012)

A total of 230 samples of processed rice and its sub-products or derived products were analysed to establish the co-occurrence of several mycotoxins. Samples were analysed in the period 2007-2009 due ...

Production of citreoviridin by Penicillium citreonigrum strains associated with rice consumption and beriberi cases in the Maranhão State, Brazil.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 27(2) , 241-8, (2010)

The aim of this study was to determine the levels of Penicillium citreonigrum and citreoviridin present in rice samples from Maranhão State, Brazil, where an outbreak of beriberi was reported and 32 d...

Effect of citreoviridin and isocitreoviridin on beef heart mitochondrial ATPase.

Arch. Biochem. Biophys. 270(2) , 714-21, (1989)

Citreoviridin is a toxic metabolite from fungus that has been shown to be an inhibitor of mitochondrial F1-ATPases. Studies of citreoviridin, however, have been compromised by the light-dependent isom...

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